Lv Dan, Wang Zepu, Li Yan, Chen Shuchun, Li Letian
Ultrasound Department, Hebei General Hospital, Shijiazhuang City, Hebei Province, China.
Department of Hepatobiliary Surgery, Hebei General Hospital, Shijiazhuang City, Hebei Province, China.
Sci Rep. 2025 Jul 1;15(1):21034. doi: 10.1038/s41598-025-07172-6.
To combine two indicators, asprosin and lipid accumulation product (LAP), to assess their predictive value for metabolic dysfunction-associated steatotic liver disease (MASLD) and to provide a more convenient and accurate option for mass screening of the MASLD population. Data were collected from 1249 adult subjects who underwent physical examination, LAP was calculated and serum asprosin was measured. Statistical analyses were performed and ROC curves were constructed to assess the predictive value of asprosin, LAP and their combination for MASLD. Asprosin and LAP levels were significantly higher in the MASLD group than in the non-MASLD group (P < 0.001), and asprosin and LAP were independent risk factors for the development of MASLD (P < 0.05).The combination of asprosin and LAP had the highest predictive efficacy for MASLD, and the AUCs were 0.841, 0.821 and 0.871 in the total, male and female populations, respectively. Asprosin and LAP are both good predictors of MASLD, and their combined performance is better than either indicator alone, and better in women than in men.The combination of asprosin and LAP may be an ideal marker for MASLD screening and individualised monitoring and management.
结合脂肪因子和脂质蓄积产物（LAP）这两个指标，评估它们对代谢功能障碍相关脂肪性肝病（MASLD）的预测价值，并为MASLD人群的大规模筛查提供一种更便捷、准确的选择。收集了1249名接受体检的成年受试者的数据，计算LAP并检测血清脂肪因子水平。进行统计分析并绘制ROC曲线，以评估脂肪因子、LAP及其联合指标对MASLD的预测价值。MASLD组的脂肪因子和LAP水平显著高于非MASLD组（P < 0.001），脂肪因子和LAP是MASLD发生的独立危险因素（P < 0.05）。脂肪因子和LAP联合对MASLD具有最高的预测效能，在总人群、男性和女性人群中的曲线下面积（AUC）分别为0.841、0.821和0.871。脂肪因子和LAP都是MASLD的良好预测指标，它们的联合表现优于单独的任何一个指标，且在女性中比在男性中表现更好。脂肪因子和LAP的联合可能是MASLD筛查以及个体化监测和管理的理想标志物。
Cochrane Database Syst Rev. 2025-6-24
Hepatology. 2023-12-1
Clin Liver Dis. 2023-5
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