Piñar-Morales Raquel, Durán Raquel, Bautista-García Alicia, García-Mansilla Maria Jose, Aliaga-Gaspar Pablo, Vives-Montero Francisco, Barrero-Hernández Francisco J
Neurology Department, Hospital Universitario Clinico San Cecilio, Granada, Spain.
University of Granada, Instituto de Investigación Biosanitaria IBS, Granada, Spain.
Sci Rep. 2025 Jul 2;15(1):22983. doi: 10.1038/s41598-025-07429-0.
Multiple sclerosis (MS) is a chronic, inflammatory and degenerative disease affecting the central nervous system, the pathophysiology of which is unknown. Oxidative stress appears to play a significant role in the initiation and the perpetuation of the inflammatory and neurodegenerative processes associated with MS. We have analysed parameters relating to oxidative stress in people with multiple sclerosis (pwMS) and in healthy individuals.Superoxide dismutase (SOD) activity was higher in pwMS than the control group. Meanwhile, total antioxidant capacity (TAC), 4-hydroxynonenal (4-HNE) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were lower in pwMS. The TAC levels correlated with age and disease duration. Regarding the relationship with disease activity, SOD levels were related to T2-FLAIR lesion burden in MRI and 8-OHdG to annualised relapse rate. PwMS with slower processing speeds exhibited lower levels of TAC and higher 4-HNE levels. No relationship was found between oxidative stress and the presence of depression, fatigue or quality of life. These results link oxidative stress to the pathogenesis of MS. Our findings suggest that these parameters might vary in function of disease activity or be related to the presence of MS-associated symptoms such as CI.
多发性硬化症（MS）是一种影响中枢神经系统的慢性、炎症性和退行性疾病，其病理生理学尚不清楚。氧化应激似乎在与MS相关的炎症和神经退行性过程的启动和持续中起重要作用。我们分析了多发性硬化症患者（pwMS）和健康个体中与氧化应激相关的参数。pwMS中超氧化物歧化酶（SOD）活性高于对照组。同时，pwMS中的总抗氧化能力（TAC）、4-羟基壬烯醛（4-HNE）和8-羟基-2'-脱氧鸟苷（8-OHdG）较低。TAC水平与年龄和病程相关。关于与疾病活动的关系，SOD水平与MRI中的T2-FLAIR病变负荷相关，而8-OHdG与年化复发率相关。处理速度较慢的pwMS表现出较低的TAC水平和较高的4-HNE水平。未发现氧化应激与抑郁、疲劳或生活质量之间存在关联。这些结果将氧化应激与MS的发病机制联系起来。我们的研究结果表明，这些参数可能会因疾病活动而有所不同，或者与CI等MS相关症状的存在有关。
