Ludlow Christy L, Adler Charles H, Berke Gerald S, Bielamowicz Steven A, Blitzer Andrew, Bressman Susan B, Hallett Mark, Jinnah H A, Juergens Uwe, Martin Sandra B, Perlmutter Joel S, Sapienza Christine, Singleton Andrew, Tanner Caroline M, Woodson Gayle E
Laryngeal and Speech Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Otolaryngol Head Neck Surg. 2008 Oct;139(4):495-505. doi: 10.1016/j.otohns.2008.05.624.
To identify research priorities to increase understanding of the pathogenesis, diagnosis, and improved treatment of spasmodic dysphonia.
A multidisciplinary working group was formed that included both scientists and clinicians from multiple disciplines (otolaryngology, neurology, speech pathology, genetics, and neuroscience) to review currently available information on spasmodic dysphonia and to identify research priorities.
Operational definitions for spasmodic dysphonia at different levels of certainty were recommended for diagnosis and recommendations made for a multicenter multidisciplinary validation study.
The highest priority is to characterize the disorder and identify risk factors that may contribute to its onset. Future research should compare and contrast spasmodic dysphonia with other forms of focal dystonia. Development of animal models is recommended to explore hypotheses related to pathogenesis. Improved understanding of the pathophysiology of spasmodic dysphonia should provide the basis for developing new treatment options and exploratory clinical trials.
This document should foster future research to improve the care of patients with this chronic debilitating voice and speech disorder by otolaryngology, neurology, and speech pathology.
确定研究重点，以增进对痉挛性发声障碍的发病机制、诊断及改善治疗的理解。
组建了一个多学科工作小组，成员包括来自多个学科（耳鼻喉科、神经科、言语病理学、遗传学和神经科学）的科学家和临床医生，以回顾目前关于痉挛性发声障碍的可用信息，并确定研究重点。
推荐了不同确定性水平下痉挛性发声障碍的操作定义用于诊断，并为一项多中心多学科验证研究提出了建议。
最优先的是对该疾病进行特征描述，并确定可能导致其发病的危险因素。未来的研究应将痉挛性发声障碍与其他形式的局灶性肌张力障碍进行比较和对比。建议开发动物模型以探索与发病机制相关的假说。对痉挛性发声障碍病理生理学的更好理解应为开发新的治疗方案和探索性临床试验提供基础。
本文档应促进未来的研究，以改善耳鼻喉科、神经科和言语病理学对患有这种慢性致残性嗓音和言语障碍患者的治疗。
