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中国一家三级眼科中心非感染性葡萄膜炎患者中眼部结节病的患病率及临床特征:一项回顾性观察研究

Prevalence and clinical characteristics of ocular sarcoidosis among non-infectious uveitis in a Chinese tertiary ophthalmic center: a retrospective observational study.

作者信息

He Daquan, Tao Tianyu, Peng Xuening, Lv Jianjie, Su Wenru

机构信息

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, Guangzhou, China.

Department of Ophthalmology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

出版信息

BMC Ophthalmol. 2025 Jul 1;25(1):386. doi: 10.1186/s12886-025-04165-x.

Abstract

BACKGROUND

The prevalence of ocular sarcoidosis (OS) varies across Asia and the application of the most recent revised diagnostic criteria has not yet been fully adopted. Thus, the prevalence of OS within the Chinese population remains uncertain. We investigate the prevalence of OS among non-infectious uveitis in China, with the Revised criteria of International Workshop on OS.

METHODS

In this study, we retrospectively reviewed the medical records of 406 patients who had undergone routine computed tomography scans between May 2019 and June 2023. The diagnosis of OS was made according to the Revised criteria of International Workshop on Ocular Sarcoidosis (IWOS). We further reviewed the clinical characteristics of four patients, including age, gender, anatomical type of uveitis, ocular manifestations, ocular examinations, visual acuity, and complications.

RESULTS

Out of 254 patients with noninfectious uveitis who completed computed tomography, 138 (54.3%) were men, and 116 (45.6%) were women, with a mean age of 38.9 years (ranging from 6 to 77 years). Among the 254 patients with non-infectious uveitis, OS accounted for 1.57% of the cases, however, Behcet's disease (14.5%) was the predominant etiology, followed by Vogt-Koyanagi-Harada disease (12.9%), retinal vasculitis (1.1%), multifocal choroiditis (1.1%), sympathetic ophthalmia (1.1%), punctate inner choroidopathy (0.7%), and acute posterior multifocal placoid pigment epitheliopathy (0.3%). The study revealed that 3 patients were diagnosed with definite OS, and 1 had presumed OS. Among 406 patients who underwent computed tomography, 0.98% (4/406) of patients met the Revised criteria of IWOS, 1.37% (4/290) of patients with uveitis, and 1.57% (4/254) of patients among non-infectious uveitis.

CONCLUSIONS

This study determined the prevalence of OS among non-infectious uveitis in China, and described the clinical characteristics of four individuals.

摘要

背景

眼部结节病(OS)在亚洲各地的患病率有所不同,最新修订的诊断标准尚未得到充分应用。因此,中国人群中OS的患病率仍不确定。我们采用眼部结节病国际研讨会修订标准,调查中国非感染性葡萄膜炎中OS的患病率。

方法

在本研究中,我们回顾性分析了2019年5月至2023年6月期间接受常规计算机断层扫描的406例患者的病历。OS的诊断依据眼部结节病国际研讨会(IWOS)修订标准。我们进一步回顾了4例患者的临床特征,包括年龄、性别、葡萄膜炎的解剖类型、眼部表现、眼部检查、视力和并发症。

结果

在完成计算机断层扫描的254例非感染性葡萄膜炎患者中,男性138例(54.3%),女性116例(45.6%),平均年龄38.9岁(6至77岁)。在254例非感染性葡萄膜炎患者中,OS占病例的1.57%,然而,白塞病(14.5%)是主要病因,其次是伏格特-小柳-原田病(12.9%)、视网膜血管炎(1.1%)、多灶性脉络膜炎(1.1%)、交感性眼炎(1.1%)、点状内层脉络膜病变(0.7%)和急性后极部多灶性扁平色素上皮病变(0.3%)。研究显示,3例患者被诊断为确诊的OS,1例为疑似OS。在接受计算机断层扫描的406例患者中,0.98%(4/406)的患者符合IWOS修订标准,葡萄膜炎患者中为1.37%(4/290),非感染性葡萄膜炎患者中为1.57%(4/254)。

结论

本研究确定了中国非感染性葡萄膜炎中OS的患病率,并描述了4例患者的临床特征。

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