Dumont M, Mazuez M
Rev Fr Gynecol Obstet. 1985 Aug-Sep;80(8-9):647-50.
The authors studied 22 cases of recurrent foetal hypotrophy (at least three small for dates infants) occurring in the absence of toxaemia or any other cause. The incidence was 22 cases out of 600 cases of small for dates infants, i.e. 3.67%, which is low. However, these cases presented definite recurrent foetal hypotrophy as the women delivered three successive infants with dysmaturity, which excludes chance of error. It is also important to relate the frequency to the number of women having delivered at least three infants, which eliminates a lot of the value of this figure of 3.67%. If we consider only those infants born to mothers with at least three children, the rate of "essential" recurrent foetal hypotrophy is 23%, which is considerable. Certain causes responsible for the recurrence of intra-uterine growth retardation may be missed, for example uterine malformations or unrecognised toxic factors. Nevertheless, the birth of three successive small for dates infants raises the possibility, at least in certain cases, of a particular factor responsible for intra-uterine growth, a regulatory factor of maternal origin, which may be genetic.
作者研究了22例反复出现胎儿生长受限的病例（至少有三个小于孕周的婴儿），这些病例均无子痫前期或任何其他病因。在600例小于孕周的婴儿中，发病率为22例，即3.67%，这一发病率较低。然而，这些病例呈现出明确的反复性胎儿生长受限，因为这些女性连续分娩了三个不成熟的婴儿，这排除了误差的可能性。将该频率与至少分娩过三个婴儿的女性数量相关联也很重要，这使得3.67%这个数字的很多价值被消除。如果我们仅考虑那些母亲至少有三个孩子的婴儿，“原发性”反复性胎儿生长受限的发生率为23%，这一比例相当可观。某些导致宫内生长迟缓复发的原因可能被遗漏，例如子宫畸形或未被识别的毒性因素。然而，连续分娩三个小于孕周的婴儿至少在某些情况下增加了存在特定因素导致宫内生长的可能性，这是一种母体来源的调节因素，可能是遗传性的。
