Morvaridi Mehrnaz, Bavi Behbahani Hossein, Alipour Meysam, Zare Javid Ahmad, Keramatzadeh Sara, Shokri Shiva, Tofighzadeh Pardis, Fayazfar Fatemeh, Soltaniyan Dehkordi Haleh, Ghadimi Elahe, Babajafari Esfandabad Siavash, Shayanpour Shokouh
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Department of Nutrition, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran.
BMC Nephrol. 2025 Jul 1;26(1):305. doi: 10.1186/s12882-025-04089-0.
Hemodialysis is crucial for individuals with end-stage renal disease (ESRD), but it poses challenges that impact health and quality of life. Malnutrition, inflammation, sleep disturbances, and mental health disorders are common among hemodialysis patients, interconnecting and influencing outcomes. Therefore, the study aimed to investigate the association between the Malnutrition-Inflammation Score (MIS) and various health parameters, including sleep quality and mental health in hemodialysis patients.
A multicenter cross-sectional study investigated the association between the MIS and health parameters in 423 hemodialysis patients across eight centers. Assessments included MIS, physical activity levels, dietary intake, sleep quality, and mental health status, along with biochemical parameters. Statistical analyses using SPSS software were conducted to identify associations.
Significant differences were observed in demographic, clinical, and biochemical characteristics across MIS quartiles (p < .05). Older age, lower BMI, longer dialysis vintage, and altered biochemical profiles were noted in higher MIS quartiles. Depression scores were significantly higher in higher MIS quartiles (p = .04). Multivariable analyses confirmed these associations, indicating higher odds of poorer sleep quality, depression, and anxiety with increasing MIS quartiles (p < .05).
The study highlights the intricate association between malnutrition, inflammation, sleep quality, and mental health conditions in hemodialysis patients. Addressing these factors comprehensively and tailoring interventions may lead to improved outcomes and well-being.
血液透析对于终末期肾病（ESRD）患者至关重要，但它带来了影响健康和生活质量的挑战。营养不良、炎症、睡眠障碍和心理健康问题在血液透析患者中很常见，它们相互关联并影响治疗结果。因此，本研究旨在调查血液透析患者的营养不良-炎症评分（MIS）与包括睡眠质量和心理健康在内的各种健康参数之间的关联。
一项多中心横断面研究调查了八个中心的423名血液透析患者中MIS与健康参数之间的关联。评估包括MIS、身体活动水平、饮食摄入、睡眠质量和心理健康状况，以及生化参数。使用SPSS软件进行统计分析以确定关联。
在MIS四分位数之间观察到人口统计学、临床和生化特征的显著差异（p < .05）。在较高的MIS四分位数中，年龄较大、BMI较低、透析时间较长和生化指标改变。较高的MIS四分位数中的抑郁评分显著更高（p = .04）。多变量分析证实了这些关联，表明随着MIS四分位数的增加，睡眠质量较差、抑郁和焦虑的几率更高（p < .05）。
该研究强调了血液透析患者营养不良、炎症、睡眠质量和心理健康状况之间的复杂关联。全面解决这些因素并量身定制干预措施可能会改善治疗结果和健康状况。
