Soleimani Damaneh Mohadeseh, Bavi Behbahani Hossein, Alipour Meysam, Zare Javid Ahmad, Keramatzadeh Sara, Shokri Shiva, Tofighzadeh Pardis, Fayazfar Fatemeh, Soltaniyan Dehkordi Haleh, Ghadimi Elahe, Babajafari Esfandabad Siavash, Shayanpour Shokouh
Department of Nutrition, School of Public Health Iran University of Medical Sciences, Tehran, Iran.
Department of Nutrition, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran.
Nutr Metab (Lond). 2025 Jul 1;22(1):69. doi: 10.1186/s12986-025-00958-5.
Poor sleep quality and mental disorders are common issues among patients undergoing dialysis. Diet and lifestyle may be associated with sleep quality and mental health. The current study aimed to evaluate the associations between the Dietary and Lifestyle Inflammation Scale (DLIS) score and mental health and sleep quality among Iranian hemodialysis patients.
This multicenter cross-sectional study was conducted on 423 patients undergoing hemodialysis at eight centers in three cities. The DLIS was calculated using information from a validated 168-item semiquantitative food frequency questionnaire. Mental health was evaluated via the 21-item Depression, Anxiety, and Stress Scale (DASS-21), and the Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality. Other assessments included physical activity levels, biochemical parameters, and patient dialysis data. Statistical analyses via SPSS software were conducted to identify associations.
The mean ± standard deviation of age and body mass index (BMI) were 52.84 ± 14.63 years and 24.8 ± 5.11 kg/m, respectively. A total of 58.9% of the participants were men. After controlling for potential confounders, participants in the top quartile of DLIS had greater odds of having poor sleep quality (OR: 3.18; 95% CI: 1.71-5.90), depression (OR: 1.94; 95% CI: 1.06-3.54), anxiety (OR: 2.82; 95% CI: 1.51-5.27), and stress (OR: 2.15; 95% CI: 1.14-4.03) than did those in the bottom quartile.
Our findings revealed that increased dietary and lifestyle inflammatory potential, characterized by increased DLIS, was positively associated with increased risks of depression, anxiety, stress and poor sleep quality.
睡眠质量差和精神障碍是透析患者常见的问题。饮食和生活方式可能与睡眠质量和心理健康有关。本研究旨在评估伊朗血液透析患者的饮食与生活方式炎症量表（DLIS）得分与心理健康和睡眠质量之间的关联。
本多中心横断面研究在三个城市的八个中心对423例接受血液透析的患者进行。DLIS通过一份经验证的168项半定量食物频率问卷中的信息计算得出。通过21项抑郁、焦虑和压力量表（DASS - 21）评估心理健康，并使用匹兹堡睡眠质量指数（PSQI）评估睡眠质量。其他评估包括身体活动水平、生化参数和患者透析数据。通过SPSS软件进行统计分析以确定关联。
年龄和体重指数（BMI）的平均值±标准差分别为52.84±14.63岁和24.8±5.11kg/m²。共有58.9%的参与者为男性。在控制潜在混杂因素后，DLIS得分处于最高四分位数的参与者出现睡眠质量差（比值比：3.18；95%置信区间：1.71 - 5.90）、抑郁（比值比：1.94；95%置信区间：1.06 - 3.54）、焦虑（比值比：2.82；95%置信区间：1.51 - 5.27）和压力（比值比：2.15；95%置信区间：1.14 - 4.03）的几率高于最低四分位数的参与者。
我们的研究结果表明，以DLIS升高为特征的饮食和生活方式炎症潜能增加与抑郁、焦虑、压力和睡眠质量差的风险增加呈正相关。
