Zeleke Tirsit Ketsela, Tamene Fasil Bayafers, Geremew Gebremariam Wulie, Alemayehu Tekletsadik Tekleslassie, Worku Minichil Chanie, Wondm Samuel Agegnew, Tefera Aschalew Mulatu, Fitgu Ayelign Eshete, Belay Wubetu Yihunie, Teym Abraham, Abebe Rahel Belete, Tegegne Bantayehu Addis
Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
BMC Psychiatry. 2025 Jul 1;25(1):609. doi: 10.1186/s12888-025-07035-4.
Mental illness and cardiovascular diseases frequently co-occur and are among the leading causes of global morbidity and mortality. Their comorbidity is associated with poorer health outcomes, including higher mortality, hospital readmissions, and increased healthcare utilization. Although mental health treatment has been shown to improve clinical outcomes, its impact on patient survival outcomes remains underexplored. This study aims to evaluate the effects of mental health treatment on hospital readmissions, emergency department visits, and overall survival time in patients with comorbid mental health and cardiovascular conditions.
A multi-center retrospective cohort study was carried out among adult comorbid mental health and cardiovascular diseases patients in Ethiopia. Data entry was performed using EpiData Manager, and the dataset was subsequently exported to SPSS version 26 for analysis. A Cox proportional hazards regression model was applied to identify factors influencing the time to hospital readmission and emergency department visits. Adjusted hazard ratios with corresponding 95% confidence intervals were reported, and statistical significance was determined at a -value threshold of < 0.05. Kaplan-Meier survival curves were used to illustrate differences in time to hospital readmission and emergency department visits between treated and untreated patients.
Depression was the most prevalent mental health condition, affecting 47.3% of participants, while hypertension was the most common cardiovascular illness in 37.3% of participants. The rate of mental health treatment in this study is 35.7%. Determinates of hospital readmission included mental health treatment AHR 3.44 (95% CI: 2.11–5.62) and the presence of comorbid conditions AHR of 1.53 (95% CI: 1.03–2.28). Additionally, emergency department visits were significantly associated with mental health treatment AHR of 2.11 (95% CI: 1.09–4.08). Kaplan-Meier survival curves indicated that patients receiving mental health treatment experienced longer times to readmission and emergency department visits compared to untreated patients.
Mental health treatment is associated with improved survival outcomes and reduced hospital readmissions and emergency department visits, in patients with comorbid mental health and cardiovascular diseases. These findings indicate the importance of integrating mental health care into the management of patients with complex medical conditions to improve long-term outcomes and reduce the burden on healthcare systems. Moreover, it is important to pay attention to patients with comorbid diseases.
Not applicable.
The online version contains supplementary material available at 10.1186/s12888-025-07035-4.
精神疾病和心血管疾病经常同时出现，是全球发病和死亡的主要原因之一。它们的共病与更差的健康结果相关，包括更高的死亡率、住院再入院率以及医疗保健利用率的增加。尽管心理健康治疗已被证明可改善临床结果，但其对患者生存结果的影响仍未得到充分探索。本研究旨在评估心理健康治疗对患有心理健康和心血管疾病共病患者的住院再入院率、急诊科就诊次数和总体生存时间的影响。
在埃塞俄比亚对患有心理健康和心血管疾病共病的成年患者进行了一项多中心回顾性队列研究。使用EpiData Manager进行数据录入，随后将数据集导出到SPSS 26版本进行分析。应用Cox比例风险回归模型来确定影响住院再入院时间和急诊科就诊时间的因素。报告调整后的风险比及相应的95%置信区间，并在α值阈值<0.05时确定统计学意义。使用Kaplan-Meier生存曲线来说明接受治疗和未接受治疗的患者在住院再入院时间和急诊科就诊时间上的差异。
抑郁症是最普遍的心理健康状况，影响了47.3%的参与者，而高血压是37.3%参与者中最常见的心血管疾病。本研究中的心理健康治疗率为35.7%。住院再入院的决定因素包括心理健康治疗（调整后风险比3.44，95%置信区间：2.11–5.62）和共病情况的存在（调整后风险比1.53，95%置信区间：1.03–2.28）。此外，急诊科就诊与心理健康治疗显著相关（调整后风险比2.11，95%置信区间：1.09–4.08）。Kaplan-Meier生存曲线表明，与未接受治疗的患者相比，接受心理健康治疗的患者再次入院和急诊科就诊的时间更长。
心理健康治疗与患有心理健康和心血管疾病共病患者的生存结果改善、住院再入院率降低以及急诊科就诊次数减少相关。这些发现表明将心理健康护理纳入复杂医疗状况患者的管理中以改善长期结果并减轻医疗保健系统负担的重要性。此外，关注患有共病的患者很重要。
不适用。
在线版本包含可在10.1186/s12888-025-07035-4获取的补充材料。
