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新发传染病的感染预防与控制措施:中国首例输入性拉沙热病例的经验教训

Infection prevention and control measures for emerging infectious disease: lessons learned from the first case of imported Lassa fever in China.

作者信息

Peng Yalan, Wang Yantong, Li Shiyu, Huang Jing, Shi Wu, Luo Ruocheng, Pan Xianmou, Huang Wenzhi, Qiao Fu, Chen Yi

机构信息

Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.

Department of Infection Control, West China Hospital, Sichuan University, Chengdu, 610041, China.

出版信息

Antimicrob Resist Infect Control. 2025 Jul 1;14(1):74. doi: 10.1186/s13756-025-01597-4.

Abstract

BACKGROUND

Lassa fever is an acute viral hemorrhagic disease prevalent in West Africa. West China Hospital of Sichuan University (WCHSCU) received China's first imported case of Lassa fever from overseas. We described the epidemiological investigation and infection prevention and control measures of this case following the confirmed diagnosis.

METHODS

An emergency epidemiological team defined close contacts and implemented infection prevention and control (IPC) measures: (1) isolation in a designated isolation room, (2) environmental disinfection for high-, medium-, and low-risk areas, (3) 21-day quarantine for contacts. Data were collected via field observations and medical records.

RESULTS

We identified 6 close contacts and 74 general contacts, who were subsequently quarantined for 21 days. The hospital environment was classified into high, medium, and low-risk areas, and corresponding cleaning and disinfection measures were implemented. Ultimately, no new infection cases emerged.

CONCLUSION

Rapid risk stratification, strict isolation protocols, and multidisciplinary coordination effectively prevented transmission, underscoring the importance of preparedness in non-endemic regions.

摘要

背景

拉沙热是一种在西非流行的急性病毒性出血热疾病。四川大学华西医院接收了中国首例境外输入性拉沙热病例。确诊后,我们描述了该病例的流行病学调查及感染预防与控制措施。

方法

一支应急流行病学团队确定了密切接触者并实施感染预防与控制(IPC)措施:(1)在指定隔离病房隔离,(2)对高、中、低风险区域进行环境消毒,(3)对接触者进行21天隔离观察。通过现场观察和病历收集数据。

结果

我们确定了6名密切接触者和74名一般接触者,随后对他们进行了21天隔离观察。医院环境被划分为高、中、低风险区域,并实施了相应的清洁和消毒措施。最终,未出现新的感染病例。

结论

快速的风险分层、严格的隔离方案以及多学科协作有效地预防了传播,凸显了非流行地区做好准备工作的重要性。

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