Elgun Tugba, Isik Ayşe Akgul, Ciraci Enver, Gundogan Gul Ipek, Ziksahna Kaan, Arslan Halil Ibrahim
Department of Medical Biology, Faculty of Medicine, Biruni University, Istanbul, Turkey.
Biruni University Research Center (B@MER), Biruni University, 34015, Istanbul, Turkey.
Endocr Metab Immune Disord Drug Targets. 2025 Jun 30. doi: 10.2174/0118715303376457250617154223.
BACKGROUND: The potential benefits of the ketogenic diet (KD) on ageing are currently receiving increasing attention. Although there are various studies on this subject in the existing literature, there is a lack of systematic review and bibliometric analysis. AIM: This study aimed to present a bibliometric overview and visualization analysis of the existing studies examining the relationship between KD and ageing, identify trends in this field, and provide a basis for future research and sustainable development goals. MATERIALS AND METHODS: This study involved a systematic review of the literature. In this study, Scopus (Elsevier) and Web of Science Core Collection (WoSCC) databases were used for bibliometric analysis. In the study, all articles, reviews, and other types of publications on KD and ageing published between 1995 and 2024 were analysed. Studies covering the years 1995-2025 and including the keywords 'ketogenic diet OR ketogenic diets OR ketone diet AND aging AND PUB YEAR > 1995 AND PUBYEAR < 2025' in the title were included. The VOSviewer software (VOSviewer v.1.6.10) was utilized to visualize the data. The data obtained were evaluated by bibliometric methods, such as keyword analysis and cluster analysis. RESULTS: A significant increase in the number of studies on KD and ageing was observed. In the study, when the data obtained from WoSCC and Scopus databases and VOSviewer analysis results were evaluated together, a total of 10,170 scientific documents in the Scopus database and a total of 168 scientific documents were identified in the Web of Science database between 1995-2025 worldwide. The author publishing the most on the subject was found to be Cunnane, S.C. The country contributing the most to the field was found to be the United States of America (USA). The institution that produced the most documents was Harvard Medical School. In a total of 10,170 records, the most preferred type of publication was articles. Nutrients journal was the journal with the highest number of publications. According to the results of keyword analysis, the words "ketogenic diet" and "aging" were the most frequently used and most strongly related words. CONCLUSION: The results of this study showed a significant increase in the number of studies investigating the effects of KD on ageing. More high-quality, randomised controlled clinical trials are needed in this field. In particular, there is a lack of studies examining the effects of KD on age-related diseases at the molecular level.
背景：生酮饮食（KD）对衰老的潜在益处目前正受到越来越多的关注。尽管现有文献中有关于该主题的各种研究，但缺乏系统综述和文献计量分析。 目的：本研究旨在对现有研究进行文献计量概述和可视化分析，以探讨KD与衰老之间的关系，确定该领域的趋势，并为未来研究和可持续发展目标提供依据。 材料与方法：本研究对文献进行了系统综述。在本研究中，使用Scopus（爱思唯尔）和科学网核心合集（WoSCC）数据库进行文献计量分析。在研究中，分析了1995年至2024年间发表的所有关于KD与衰老的文章、综述和其他类型的出版物。纳入了涵盖1995 - 2025年且标题中包含关键词“生酮饮食或生酮饮食或酮饮食与衰老以及出版年份>1995且出版年份<2025”的研究。使用VOSviewer软件（VOSviewer v.1.6.10）对数据进行可视化。通过关键词分析和聚类分析等文献计量方法对获得的数据进行评估。 结果：观察到关于KD与衰老的研究数量显著增加。在该研究中，当将从WoSCC和Scopus数据库获得的数据与VOSviewer分析结果一起评估时，在1995 - 2025年全球范围内，Scopus数据库中共有10170篇科学文献，科学网数据库中共有168篇科学文献。发现该主题发文最多的作者是Cunnane, S.C.。对该领域贡献最大的国家是美利坚合众国（美国）。产出文献最多的机构是哈佛医学院。在总共10170条记录中，最受欢迎的出版物类型是文章。《营养素》杂志是发文数量最多的期刊。根据关键词分析结果，“生酮饮食”和“衰老”是使用最频繁且相关性最强的词汇。 结论：本研究结果表明，研究KD对衰老影响的研究数量显著增加。该领域需要更多高质量的随机对照临床试验。特别是，缺乏在分子水平上研究KD对与年龄相关疾病影响的研究。
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