Wong Li Ping, Lee Hai Yen, Alias Haridah, Nguyen Di Khanh, Lachyan Abhishek, Seheli Farhana Nishat, Ahmed Jamil, Hu Zhijian, Lin Yulan
Centre for Population Health (CePH), Department of Social and Preventive Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.
Hum Vaccin Immunother. 2025 Dec;21(1):2526231. doi: 10.1080/21645515.2025.2526231. Epub 2025 Jul 1.
This study seeks to investigate willingness to receive vaccination against NTDs using mRNA-based vaccines in various Asian countries, including China. Between June and December 2023, an anonymous cross-sectional survey was carried out in five countries. The survey assessed knowledge and attitudes regarding mRNA vaccines and their potential impact on vaccination acceptance. The majority indicated being somewhat willing (44.9%), 19.3% expressed extreme willingness. High knowledge scores (adjusted odds ratio [aOR] = 2.61, 95% confidence interval (CI): 2.31-2.96] were associated with higher willingness to receive mRNA-based NTD vaccines. Participants from Bangladesh recorded the highest proportion expressed willingness (51.4%), followed by China (15.9%). Vietnam (15.4%) and Malaysia (14.8%). Pakistan (11.0%) and India (11.3%) recorded lowest proportions of willingness. Understanding the mechanism of mRNA vaccines and awareness of the difference between mRNA vaccines and conventional ones are knowledge items that significantly predict acceptance. Concerns regarding potential unknown side effects associated with mRNA-based approaches, and the perception that traditional vaccine development methods are safer, negatively correlate with willingness. Conversely, the belief in the advantages of mRNA-based approaches, such as rapid development, heightened potency, and reduced cost, positively correlates with willingness. High overall knowledge and attitudes scores were associated with a higher willingness to receive vaccines. The younger age group and females demonstrated a greater vaccination acceptance. Overall, the study highlights both opportunities and challenges in promoting the uptake of mRNA-based vaccines against NTDs in Asia countries. The study provides insights into enhancing knowledge and fostering positive attitudes toward mRNA-based vaccines.
本研究旨在调查包括中国在内的亚洲各国使用基于信使核糖核酸（mRNA）的疫苗预防被忽视热带病（NTDs）的意愿。2023年6月至12月期间，在五个国家开展了一项匿名横断面调查。该调查评估了关于mRNA疫苗的知识和态度及其对疫苗接种接受度的潜在影响。大多数人表示有点愿意（44.9%），19.3%表示非常愿意。高知识得分（调整优势比[aOR]=2.61，95%置信区间[CI]：2.31-2.96）与接受基于mRNA的NTD疫苗的意愿较高相关。来自孟加拉国的参与者表示愿意的比例最高（51.4%），其次是中国（15.9%）。越南（15.4%）和马来西亚（14.8%）。巴基斯坦（11.0%）和印度（11.3%）表示愿意的比例最低。了解mRNA疫苗的机制以及对mRNA疫苗与传统疫苗差异的认识是显著预测接受度的知识项目。对基于mRNA方法潜在未知副作用的担忧，以及认为传统疫苗开发方法更安全的看法，与意愿呈负相关。相反，对基于mRNA方法优势的信念，如快速开发、效力增强和成本降低，与意愿呈正相关。总体知识和态度得分高与接受疫苗的意愿较高相关。较年轻年龄组和女性表现出更高的疫苗接种接受度。总体而言，该研究凸显了在亚洲国家推广使用基于mRNA的NTD疫苗的机遇和挑战。该研究为增强对基于mRNA疫苗的知识和培养积极态度提供了见解。
