Wang Tengyue, Zhou Kai, Zhou Xiaoyan, Wang Xiaoming, Xing Haoyang, Li Rong, Liao Wei, Yu Jiali, Lu Fengmei, Hu Xiaofei, Chen Huafu, Gao Qing
School of Mathematical Sciences, The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
Health Management Center, Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, People's Republic of China.
Hum Brain Mapp. 2025 Jul;46(10):e70268. doi: 10.1002/hbm.70268.
Cerebellum has a stronger individual specificity of functional signals than the brain and is associated with a variety of neuropsychiatric disorders, and increasing attention is being paid to neuropsychiatric symptoms caused by cerebellar dysfunction. However, there is a lack of a suitable cerebellar partition utilizing researchers to fully understand the functional and structural organization of the cerebellum, reduce data dimensionality, and improve the applicability of various types of models to cerebellar functional imaging data, impeding progress in cerebellum-related research. In this study, we use order-preserving variations with spatial constraints to optimize functional connectivity matrices and employ a spectral clustering algorithm combined with a clustering ensemble technique to construct a cerebellar partitioning algorithm with a variable number of partitions. Our method was initially validated by using two separate sets of functional magnetic resonance data (fMRI), demonstrating high reproducibility across individuals. Comparative analysis revealed that our partitions exhibited enhanced signal coherence and greater spatial congruence with established cerebellar structural templates compared to four publicly available cerebellar atlases. Furthermore, preliminarily applying these partitions to Parkinson's disease (PD) data, we extracted cerebellar connectivity network features and constructed a classification model using a logistic regression model with L2 regularization. The connectivity features derived from our newly constructed cerebellar partitions substantially improved the usability of the Parkinson's classification model, with the classification of PD optimized at a number of partitions equal to 185, suggesting that the optimal number of cerebellar partitions may also vary based on the problem under study. Notably, cerebellar regions implicated in motor execution were identified to exhibit higher feature importance in the Parkinson's classification model, offering an important direction for feature selection in the multimodal classification models of PD.
小脑的功能信号具有比大脑更强的个体特异性,并且与多种神经精神疾病相关,因此小脑功能障碍引起的神经精神症状越来越受到关注。然而,目前缺乏一种合适的小脑分区方法,这使得研究人员难以充分理解小脑的功能和结构组织、降低数据维度以及提高各种模型对小脑功能成像数据的适用性,从而阻碍了小脑相关研究的进展。在本研究中,我们使用具有空间约束的保序变化来优化功能连接矩阵,并采用谱聚类算法结合聚类集成技术构建了一种可变分区数量的小脑分区算法。我们的方法首先通过使用两组独立的功能磁共振数据(fMRI)进行了验证,证明了个体间的高重现性。比较分析表明,与四个公开可用的小脑图谱相比,我们的分区在信号相干性方面表现更优,并且与已建立的小脑结构模板在空间上具有更高的一致性。此外,将这些分区初步应用于帕金森病(PD)数据时,我们提取了小脑连接网络特征,并使用带有L2正则化的逻辑回归模型构建了一个分类模型。从我们新构建的小脑分区中导出的连接特征显著提高了帕金森病分类模型的可用性,在分区数量等于185时,PD的分类效果达到最优,这表明小脑分区的最优数量可能也会因所研究的问题而异。值得注意的是,在帕金森病分类模型中,与运动执行相关的小脑区域被确定为具有更高的特征重要性,这为PD多模态分类模型中的特征选择提供了一个重要方向。
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