Zhu Jia-Hui, Liu Xiao, Zhou Wei, Xu Xiao-Nan, Sheng Wen-Da, Han Yi-Lin, Qiu Xiao-Ou, Liu Ya-Wei, Qian Yang-Yang, Liao Zhuan, Li Zhao-Shen
Department of Gastroenterology and Endoscopy, Eastern Hepatobiliary Surgery Hospital, The Naval Medical University, Shanghai 200438, China.
Department of Digestive Diseases, National Clinical Research Center, Shanghai 200433, China.
World J Gastroenterol. 2025 Jun 28;31(24):105823. doi: 10.3748/wjg.v31.i24.105823.
The clinical effectiveness of magnetically controlled capsule endoscopy (MCE) is well established. However, problems, such as abdominal distension, insufficient gastric filling, and prolonged gastric retention time, persist with MCE gastric preparations.
To compare gastric filling using a carbonated soft drink with that using pure water during MCE.
We performed an open-label randomised controlled trial at the Endoscopy Centre of Changhai Hospital in Shanghai. Patients aged 18-80 years, with or without gastrointestinal symptoms, scheduled for MCE were consecutively recruited. Those who provided informed consent were randomly assigned to the carbonated soft drink group (C group) or water group (W group) in a 1:1 ratio. For patients in the W group, 1000 mL of water was ingested to distend the stomach, whereas for patients in the C group, 550 mL of carbonated soft drink was provided, and patients were required to drink quickly while minimising burping. The primary endpoint was the number of patients with a gastric filling score of ≥ 4 within 5 minutes after the capsule entered the stomach.
From December 3, 2020 to May 17, 2021, 252 patients (141 men), aged 18-77 years, were assigned to the C ( = 126) and W ( = 126) groups. For the primary outcome, 123 patients in the C group achieved a gastric filling score of ≥ 4 (97.62% 80.16%, < 0.0001). More patients in the C group had the highest gastric filling scores within the first 5 min (78.57% 29.37%, < 0.0001) and 10 minutes (54.76% 13.49%, < 0.0001) after the capsule entered the stomach. More patients in the W group required extra liquid for gastric refilling (1.59% 16.67%, < 0.0001). Transpyloric passage of the capsule under magnetic control was successfully performed in 43 patients in the C group ( < 0.0001), accompanied by a shorter gastric transit time (53.27 ± 53.83 minutes 71.12 ± 52.19 minutes, = 0.001).
Carbonated soft drinks demonstrated superior and more sustained gastric filling compared with those of water alone, with the potential to promote gastric emptying.
磁控胶囊内镜检查（MCE）的临床有效性已得到充分证实。然而，MCE胃部准备仍存在腹胀、胃充盈不足和胃潴留时间延长等问题。
比较MCE期间使用碳酸软饮料和使用纯水进行胃充盈的情况。
我们在上海长海医院内镜中心进行了一项开放标签随机对照试验。连续招募计划进行MCE的18 - 80岁患者，有无胃肠道症状均可。那些提供知情同意书的患者按1:1比例随机分配到碳酸软饮料组（C组）或水组（W组）。对于W组患者，摄入1000 mL水以扩张胃部，而对于C组患者，提供550 mL碳酸软饮料，要求患者快速饮用并尽量减少打嗝。主要终点是胶囊进入胃后5分钟内胃充盈评分≥4的患者数量。
2020年12月3日至2021年5月17日，252例患者（141例男性），年龄18 - 77岁，被分配到C组（n = 126）和W组（n = 126）。对于主要结局，C组123例患者胃充盈评分≥4（97.62%对80.16%，P < 0.0001）。C组更多患者在胶囊进入胃后的前5分钟（78.57%对29.37%，P < 0.0001）和10分钟（54.76%对13.49%，P < 0.0001）内达到最高胃充盈评分。W组更多患者需要额外液体进行胃再充盈（1.59%对16.67%，P < 0.0001）。C组43例患者成功进行了磁控下胶囊经幽门通过（P < 0.0001），同时胃转运时间更短（53.27±53.83分钟对71.12±52.19分钟，P = 0.001）。
与单独用水相比，碳酸软饮料显示出更好且更持久的胃充盈效果，具有促进胃排空的潜力。
