Wang Shanqing, Zhu Zicong, Shih Yanting, Zhang Yun, Liao Yong, Chen Xiaoying
Aesthet Surg J Open Forum. 2025 May 27;7:ojaf046. doi: 10.1093/asjof/ojaf046. eCollection 2025.
Skin photoaging significantly affects skin health and aesthetics, with undesirable appearances negatively impact individual psychological well-being. Intradermal injection of cross-linked hyaluronic acid (HA) has been successfully utilized to improve facial skin photoaging. However, the correlations between the number of treatments and therapeutic efficacy, as well as the dosage and therapeutic outcomes of intradermal injections of cross-linked HA, remain underexplored.
The authors observe the effects of intradermal injection of cross-linked HA in different doses and frequencies on improving facial skin photoaging.
A randomized, split-face design with participant blinding, self-controlled, prospective clinical study was conducted to evaluate the efficacy of different dosages of intradermal injections of cross-linked HA in improving mild-to-moderate female facial photoaging.
Cross-linked HA significantly improved facial photoaging scores, reduced transepidermal water loss, enhanced skin elasticity, and increased patients' satisfaction. The effects were cumulative following sequential treatments, with the high-dosage group demonstrating superior efficacy and longer lasting outcomes compared with the low-dosage group.
High-dosage, multisession intradermal injection protocols of cross-linked HA offer more effective improvements in the manifestations of facial photoaging, with superior efficacy and longer lasting outcomes.
皮肤光老化严重影响皮肤健康和美观，其不良外观会对个体心理健康产生负面影响。皮内注射交联透明质酸（HA）已成功用于改善面部皮肤光老化。然而，治疗次数与治疗效果之间的相关性，以及皮内注射交联HA的剂量与治疗结果之间的关系仍未得到充分研究。
作者观察不同剂量和频率的皮内注射交联HA对改善面部皮肤光老化的效果。
采用随机、分脸设计，对参与者进行盲法、自身对照、前瞻性临床研究，以评估不同剂量皮内注射交联HA改善轻度至中度女性面部光老化的疗效。
交联HA显著改善面部光老化评分，减少经表皮水分流失，增强皮肤弹性，并提高患者满意度。连续治疗后效果具有累积性，与低剂量组相比，高剂量组疗效更佳，效果持续时间更长。
高剂量、多次皮内注射交联HA方案对面部光老化表现的改善更有效，疗效更佳，效果持续时间更长。
