透明质酸的吸收、代谢、功能及其与微生物联合的治疗前景：综述

Absorption, metabolism, and functions of hyaluronic acid and its therapeutic prospects in combination with microorganisms: A review.

作者信息

Zheng Xueli, Wang Botao, Tang Xin, Mao Bingyong, Zhang Qiuxiang, Zhang Tianmeng, Zhao Jianxin, Cui Shumao, Chen Wei

机构信息

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Bloomage Biotechnology Co., Ltd, Jinan 250000, China.

出版信息

Carbohydr Polym. 2023 Jan 1;299:120153. doi: 10.1016/j.carbpol.2022.120153. Epub 2022 Sep 26.

DOI:10.1016/j.carbpol.2022.120153

PMID:36876779

Abstract

Hyaluronic acid (HA) is key to the stability of the internal environment of tissues. HA content in tissues gradually decreases with age, causing age-related health problems. Exogenous HA supplements are used to prevent or treat these problems including skin dryness and wrinkles, intestinal imbalance, xerophthalmia, and arthritis after absorption. Moreover, some probiotics are able to promote endogenous HA synthesis and alleviate symptoms caused by HA loss, thus introducing potential preventative or therapeutic applications of HA and probiotics. Here, we review the oral absorption, metabolism, and biological function of HA as well as the potential role of probiotics and HA in increasing the efficacy of HA supplements.

摘要

透明质酸（HA）是组织内环境稳定的关键。随着年龄增长，组织中的HA含量逐渐降低，从而引发与衰老相关的健康问题。外源性HA补充剂在吸收后用于预防或治疗这些问题，包括皮肤干燥和皱纹、肠道失衡、干眼症和关节炎。此外，一些益生菌能够促进内源性HA的合成，并减轻HA流失引起的症状，从而引入了HA和益生菌潜在的预防或治疗应用。在此，我们综述了HA的口服吸收、代谢和生物学功能，以及益生菌和HA在提高HA补充剂疗效方面的潜在作用。