Dayan Steven, Gandhi Nimit, Carvajal Catherine, Nguyen Thu Q, El-Qadi Sami, Garimella Sindhu, Meckfessel Matthew
Aesthet Surg J Open Forum. 2025 Apr 18;7:ojaf026. doi: 10.1093/asjof/ojaf026. eCollection 2025.
Injection of neuromodulators, such as botulinum toxins, is a common procedure. Used on-label, neuromodulators are safe and effective, but injection is often accompanied by pain.
The aim of the study is to understand whether administration of botulinum toxin injections with a vibration device improves patient comfort.
This single-center, randomized, split-face, controlled study evaluated 1 treatment session with botulinum toxin A (5 injection points) for correction of moderate-to-severe glabellar lines administered ± a vibrating beauty bar to improve comfort. After treating the corrugator muscle on 1 side, vibration was added or discontinued for the other side according to randomization; patients selected the method for procerus muscle injection. Patients were aged 18 to 64 and treatment naive. Pain was assessed on a visual analog scale (0 = none, 10 = worst imaginable), and questionnaires assessed treatment experience and preference.
Sixty patients completed the study. Mean pain assessment score for the group was 4.9 (standard deviation [SD] = 2.1) for injections administered without vibration compared with 4.0 (SD = 2.2) for those with vibration. Those with the first 2 injections with vibration reported a mean pain of 3.8, which increased to 4.8 for injections without vibration. Results were numerically higher for patients who had the first 2 injections without vibration, with mean scores of 4.9 without vibration and 4.2 with vibration. Investigator pain assessments were similar. Most (81.7%) patients chose vibration for the fifth injection. Patients had a positive perception of added vibration.
Both patients and investigators reported reduced pain/improved comfort when a vibration device was paired with the aesthetic treatment injection.
: 2 (Therapeutic).
注射神经调节剂，如肉毒毒素，是一种常见的操作。按标签使用时，神经调节剂是安全有效的，但注射时常伴有疼痛。
本研究的目的是了解使用振动装置进行肉毒毒素注射是否能提高患者的舒适度。
这项单中心、随机、半脸对照研究评估了1次使用A型肉毒毒素（5个注射点）治疗中度至重度眉间纹的疗程，注射时±使用振动美容棒以提高舒适度。在治疗一侧皱眉肌后，根据随机分组，另一侧添加或停止振动；患者选择降眉间肌注射的方法。患者年龄在18至64岁之间，且未曾接受过该治疗。使用视觉模拟量表（0 = 无疼痛，10 = 难以想象的剧痛）评估疼痛，并通过问卷评估治疗体验和偏好。
60名患者完成了研究。未使用振动进行注射时，该组的平均疼痛评估评分为4.9（标准差[SD]=2.1）；使用振动时为4.0（SD = 2.2）。前2次注射使用振动的患者报告的平均疼痛为3.8，未使用振动的注射疼痛增至4.8。前2次注射未使用振动的患者结果在数值上更高，未使用振动时的平均评分为4.9，使用振动时为4.2。研究者的疼痛评估结果相似。大多数（81.7%）患者在第5次注射时选择了振动。患者对添加振动有积极的感受。
患者和研究者均报告，当振动装置与美容治疗注射配合使用时，疼痛减轻/舒适度提高。
2（治疗性）。
