Shorvon S D, Reynolds E H
Br Med J. 1977 Jun 25;1(6077):1635-7. doi: 10.1136/bmj.1.6077.1635.
A retrospective survey of 50 adult epileptic outpatients who were taking two anticonvulsants drugs showed that seizure control had improved in the six months after the introduction of the second drug in only 36%. When blood concentrations of the two anticonvulsants were subsequently measured improvement in seizure control was found to be significantly related to the presence of optimum blood concentrations of at least one drug. Much unnecessary polypharmacy in the treatment of epilepsy could be avoided by ensuring an optimum blood concentration of one drug before considering the addition of a second.
一项对50名正在服用两种抗惊厥药物的成年癫痫门诊患者的回顾性调查显示，在引入第二种药物后的六个月内，只有36%的患者癫痫发作得到了改善。随后对两种抗惊厥药物的血药浓度进行测量时发现，癫痫发作控制的改善与至少一种药物达到最佳血药浓度显著相关。在考虑添加第二种药物之前，通过确保一种药物达到最佳血药浓度，可以避免癫痫治疗中许多不必要的联合用药。
