SomaScan生物信息学：标准化、质量控制及分析前变异评估
SomaScan Bioinformatics: Normalization, Quality Control, and Assessment of Pre-Analytical Variation.
作者信息
Candia Julián
机构信息
Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
出版信息
Methods Mol Biol. 2025;2929:107-127. doi: 10.1007/978-1-0716-4595-6_9.
SomaScan is an aptamer-based proteomics assay designed for the simultaneous measurement of thousands of human proteins with a broad range of endogenous concentrations. In its most current version released on November 1, 2023, the 11K SomaScan assay v5.0 is capable of measuring 10,776 human proteins covering major biological processes and disease areas, including cardiology, inflammation, neurology, and oncology. Here, I review bioinformatic approaches to perform normalization, quality control, and variability assessments.
SomaScan是一种基于适配体的蛋白质组学检测方法，旨在同时测量数千种内源性浓度范围广泛的人类蛋白质。在2023年11月1日发布的最新版本中，11K SomaScan检测方法v5.0能够测量10776种人类蛋白质，涵盖主要生物过程和疾病领域，包括心脏病学、炎症、神经学和肿瘤学。在此，我回顾了用于进行标准化、质量控制和变异性评估的生物信息学方法。
Zotero 插件