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中国采用病灶内注射葡萄糖酸锑钠对输入性旧大陆皮肤利什曼病进行综合诊断与成功治疗:1例报告

Integrated diagnosis and successful treatment of imported old world cutaneous leishmaniasis with intralesional sodium stibogluconate in china: a case report.

作者信息

Xu Junzhu, Xia Xiujiao, Liu Zehu

机构信息

Department of Dermatology, Hangzhou Third People's Hospital, No. 38 West Lake Avenue Road, Hangzhou, 310009, Zhejiang, China.

出版信息

Parasitol Res. 2025 Jul 2;124(7):75. doi: 10.1007/s00436-025-08524-x.

DOI:10.1007/s00436-025-08524-x
PMID:40601159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12222432/
Abstract

This study presents the case of a 54-year-old woman, otherwise healthy, who presented with a 4-month history of red plaques with central ulceration, which had initially developed from painless papules. The lesions appeared on her right arm and trunk, two months after her travel to Morocco. Physical examination revealed a 7 cm × 5 cm red plaque with central ulceration and crusting on her right arm, along with papules and plaques on her trunk. Based on microbiological, histopathological, and PCR results, the patient was diagnosed with Old World cutaneous leishmaniasis. After receiving two sessions of intralesional pentavalent antimonial treatment, the patient was left with only a minor scar and experienced negligible side effects, except for moderate aching during therapy.

摘要

本研究报告了一名54岁的健康女性病例,她出现了4个月的红色斑块伴中央溃疡病史,最初由无痛性丘疹发展而来。这些病变出现在她的右臂和躯干上,是在她前往摩洛哥旅行两个月后出现的。体格检查发现她右臂有一个7厘米×5厘米的红色斑块,中央溃疡并有结痂,同时躯干上有丘疹和斑块。根据微生物学、组织病理学和聚合酶链反应结果,该患者被诊断为旧世界皮肤利什曼病。在接受了两疗程的病灶内五价锑治疗后,患者仅留下轻微疤痕,除治疗期间有中度疼痛外,副作用可忽略不计。

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本文引用的文献

1
The Sporadic cutaneous leishmaniasis due to Leishmania infantum in Morocco: A presumably trend towards endemicity.摩洛哥由婴儿利什曼原虫引起的散发型皮肤利什曼病:一种可能的流行趋势。
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Epidemiological features of a recent zoonotic cutaneous leishmaniasis outbreak in Zagora province, southern Morocco.
摩洛哥南部扎古拉省近期人源皮肤利什曼病暴发的流行病学特征。
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Intralesional sodium stibogluconate under inhaled anesthesia for the treatment of cutaneous leishmaniasis in children: A retrospective cohort.吸入麻醉下病灶内注射葡萄糖酸锑钠治疗儿童皮肤利什曼病:一项回顾性队列研究
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Successful treatment against American cutaneous leishmaniasis by intralesional infiltration of a generic antimonial compound-lidocaine combination. A follow up study.通过病灶内注射一种普通锑化合物-利多卡因组合成功治疗美洲皮肤利什曼病。一项随访研究。
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6
Efficacy of pentavalent antimoniate intralesional infiltration therapy for cutaneous leishmaniasis: A systematic review.五价锑酸盐病灶内注射疗法治疗皮肤利什曼病的疗效:一项系统评价。
PLoS One. 2017 Sep 19;12(9):e0184777. doi: 10.1371/journal.pone.0184777. eCollection 2017.
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A 45 year old man with an ulcerated nodule on his right leg.一名45岁男性,右腿有一个溃疡结节。
BMJ. 2014 Sep 8;349:g5296. doi: 10.1136/bmj.g5296.
8
Leishmania tropica in children: a retrospective study.儿童内脏利什曼病:一项回顾性研究。
J Am Acad Dermatol. 2014 Aug;71(2):271-7. doi: 10.1016/j.jaad.2013.12.047. Epub 2014 Apr 26.
9
Cutaneous leishmaniasis caused by Leishmania major in morocco: still a topical question.摩洛哥的主要利什曼原虫引起的皮肤利什曼病:仍是一个热门话题。
East Mediterr Health J. 2013 May;19(5):495-501.
10
Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update.美国皮肤和黏膜利什曼病的干预措施:系统评价更新。
PLoS One. 2013 Apr 29;8(4):e61843. doi: 10.1371/journal.pone.0061843. Print 2013.