Fischbein A, Rohl A N, Suzuki Y, Bigman O
Toxicol Lett. 1985 Sep;27(1-3):51-7. doi: 10.1016/0378-4274(85)90119-5.
Interstitial pulmonary fibrosis (IPF) is often of uncertain etiology and is therefore named 'idiopathic' pulmonary fibrosis. Some occupational exposures, however, are known to cause interstitial fibrosis, asbestos and silica being well-known examples. We present clinical and pathological findings of a case with IPF and the results of microchemical analysis of inorganic particulate matter in the lung tissue. A very high lung burden of inorganic contaminants was found, including silica and metallic compounds. Emphasis is given to the importance of obtaining detailed occupational histories and conducting microchemical analysis of lung tissue in order to clarify etiological factors in cases with 'idiopathic' pulmonary fibrosis.
间质性肺纤维化(IPF)的病因通常不明,因此被称为“特发性”肺纤维化。然而,已知一些职业暴露可导致间质性纤维化,石棉和二氧化硅就是众所周知的例子。我们报告了一例IPF患者的临床和病理 findings 以及肺组织中无机颗粒物的微化学分析结果。发现肺中无机污染物的负荷非常高,包括二氧化硅和金属化合物。强调了获取详细职业史和对肺组织进行微化学分析对于明确“特发性”肺纤维化病例病因的重要性。