Kang Chunya, Kang Eugene Yu-Chuan, Chou Hung-Da, Wang Nan-Kai, Chen Kuan-Jen, Hwang Yih-Shiou, Wu Wei-Chi, Lai Chi-Chun
Department of Education, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan.
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Retina. 2025 Dec 1;45(12):2413-2419. doi: 10.1097/IAE.0000000000004556.
This study investigated the use of human amniotic membrane graft transplantation for treating recurrent large macular holes in highly myopic patients, particularly in cases resistant to standard surgical methods.
Seven eyes from six highly myopic patients with recurrent large macular holes (>400 µ m) underwent human amniotic membrane transplantation supported by perfluorocarbon liquid and ophthalmic viscoelastic devices. All patients had previously undergone pars plana vitrectomy with internal limiting membrane peeling. The human amniotic membrane graft, sized to cover the macular area, was carefully positioned with perfluorocarbon liquid and ophthalmic viscoelastic device assistance to enhance surgical control and prevent graft displacement.
Complete macular hole closure was achieved in most cases. Best-corrected visual acuity was either preserved or improved, with no complications such as retinal detachment or graft displacement. The modified technique also reduced the need for prolonged prone positioning, minimizing postoperative discomfort for patients.
Human amniotic membrane graft transplantation with perfluorocarbon liquid and ophthalmic viscoelastic device is a safe and effective method for managing large, recurrent macular holes in highly myopic eyes. This technique enhances graft handling, simplifies surgery, and achieves high closure rates with stable visual outcomes, offering a promising solution when conventional methods are inadequate.
本研究探讨人羊膜移植术在治疗高度近视患者复发性大黄斑裂孔中的应用，尤其是对标准手术方法耐药的病例。
6例高度近视患者的7只眼患有复发性大黄斑裂孔（>400μm），接受了全氟碳液和眼科粘弹剂辅助下人羊膜移植术。所有患者此前均接受过玻璃体切割联合内界膜剥除术。将尺寸能覆盖黄斑区的人羊膜移植物，在全氟碳液和眼科粘弹剂的辅助下小心定位，以增强手术控制并防止移植物移位。
大多数病例实现了黄斑裂孔完全闭合。最佳矫正视力得以保留或提高，未出现视网膜脱离或移植物移位等并发症。改良技术还减少了长时间俯卧位的需求，将患者术后不适降至最低。
全氟碳液和眼科粘弹剂辅助下人羊膜移植术是治疗高度近视眼中大的复发性黄斑裂孔的一种安全有效的方法。该技术提高了移植物的操作便利性，简化了手术，实现了高闭合率且视力结果稳定，在传统方法不足时提供了一种有前景的解决方案。
