Gion M, Mione R, Dittadi R, Griggio L, Munegato G, Valescchi M, Del Maschio O, Fasan S, Bruscagnin G
Tumori. 1985 Oct 31;71(5):477-81. doi: 10.1177/030089168507100511.
Since 1983 we have studied the relationship, in the same patient, between receptor status in breast carcinoma and in nonmalignant breast tissue. Fifty patients have been evaluated to date. The total unoccupied cytosol estrogen and progesterone receptors were determined by a dextran-coated charcoal method. In nonmalignant breast tissue we found a measurable receptor concentration above the sensitivity of the method in 62% of cases for estrogen receptors and in 44% of cases for progesterone receptors. No relationships were found between the receptor level of each tumor and that of the corresponding benign tissue. The data suggest that the levels of the receptors in the tumor and in the nonmalignant tissue are totally independent.
自1983年以来，我们研究了同一患者乳腺癌组织和非恶性乳腺组织中受体状态之间的关系。迄今为止，已对50名患者进行了评估。通过葡聚糖包被活性炭法测定总未占据细胞质雌激素和孕激素受体。在非恶性乳腺组织中，我们发现，雌激素受体在62%的病例中以及孕激素受体在44%的病例中，受体浓度可测且高于该方法的灵敏度。未发现每个肿瘤的受体水平与其相应良性组织的受体水平之间存在关联。数据表明，肿瘤组织和非恶性组织中的受体水平完全独立。
