Tinnemans J G, Beex L V, Wobbes T, Sluis R F, Raemaekers J M, Benraad T
Department of General Surgery, St. Radboud University Hospital, Nijmegen, The Netherlands.
Cancer. 1990 Sep 15;66(6):1165-7. doi: 10.1002/1097-0142(19900915)66:6<1165::aid-cncr2820660615>3.0.co;2-u.
Tumors of five groups of patients, with (1) nonpalpable primary breast cancer, (2) palpable operable primary breast cancer, (3) loco-regionally advanced primary breast cancer, (4) first and (5) late metastatic breast cancer, were studied in respect to their steroid receptor content. A statistically significant decrease of progesterone receptor positive tumors and of tumors positive for estradiol and progesterone receptors, was found with increasing advance of the disease. A reversed extrapolation of these figures supports the hypothesis that every breast cancer contains steroid receptors and is hormone-dependent from its inception.
对五组患者的肿瘤进行了研究，这些患者分别患有（1）不可触及的原发性乳腺癌、（2）可触及的可手术原发性乳腺癌、（3）局部区域晚期原发性乳腺癌、（4）首发转移性乳腺癌和（5）晚期转移性乳腺癌，研究其类固醇受体含量。随着疾病进展，发现孕酮受体阳性肿瘤以及雌二醇和孕酮受体均阳性的肿瘤在统计学上显著减少。对这些数据进行反向推断支持了这样的假设，即每一例乳腺癌从一开始就含有类固醇受体且依赖激素。
