Koletsou Ellie, Huppertz Ina
Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Straße 9b, 50931, Cologne, Germany.
University of Cologne, Faculty of Mathematics and Natural Sciences, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Joseph-Stelzmann-Straße 26, 50931, Cologne, Germany.
NPJ Metab Health Dis. 2025 Jan 13;3(1):1. doi: 10.1038/s44324-024-00044-z.
Metabolic shifts are a hallmark of numerous biological processes, including the differentiation of stem cells along a specific lineage and the activation of diverse cell types, such as immune cells. This review examines the intricate energy metabolic alterations that occur in diverse biological settings, from embryonic development to adult tissue homoeostasis and disease states. In particular, we emphasise the regulatory function of RNA-binding proteins (RBPs) in coordinating these metabolic shifts and examine how they modulate key pathways, such as glycolysis and oxidative phosphorylation, to meet the dynamic cellular energy demands. This review highlights the various mechanisms by which RBPs regulate these changes, ranging from active involvement in the post-transcriptional regulation of metabolically relevant genes to alteration of an RBP's function by specific RNAs, metabolites or growth factors. Finally, we consider how ageing and disease affect the function of RBPs and how RBPs can disrupt the delicate balance of metabolic regulation. Taken together, this review provides a comprehensive overview of the critical interplay between RBPs and metabolism and offers insights into potential therapeutic targets for regenerative medicine and age-related diseases.
代谢转变是众多生物学过程的标志，包括干细胞沿特定谱系的分化以及多种细胞类型（如免疫细胞）的激活。本综述探讨了从胚胎发育到成体组织稳态和疾病状态等不同生物学环境中发生的复杂能量代谢改变。特别地，我们强调了RNA结合蛋白（RBPs）在协调这些代谢转变中的调节功能，并研究它们如何调节关键途径，如糖酵解和氧化磷酸化，以满足细胞动态的能量需求。本综述突出了RBPs调节这些变化的各种机制，从积极参与代谢相关基因的转录后调控到特定RNA、代谢物或生长因子对RBP功能的改变。最后，我们考虑衰老和疾病如何影响RBPs的功能以及RBPs如何破坏代谢调节的微妙平衡。综上所述，本综述全面概述了RBPs与代谢之间的关键相互作用，并为再生医学和与年龄相关疾病的潜在治疗靶点提供了见解。
