Kamali Khadijeh, Hadizadeh Talasaz Fatemeh, Tabatabaei Zadeh Seyed Amir, Khajavian Nasim, Dashti Sareh, Bahri Narjes
Department of Midwifery, Faculty of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.
Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
Sci Rep. 2025 Jul 2;15(1):23072. doi: 10.1038/s41598-025-08576-0.
The hormonal changes in menopause predispose women to health risks, including type 2 diabetes. Therefore, diabetes prevention in this age group is important. Considering the fewer side effects of herbal medicines compared to chemical drugs, the present study investigated the impact of barley savigh consumption on blood sugar levels in pre-diabetic postmenopausal women. This randomized clinical trial study was conducted on 64 pre-diabetic postmenopausal women referred to Community Health Centers in Gonabad city, Iran. The intervention group (n = 32) received 60 g of barley savigh daily (20 g before each meal), and the control group (n = 32) received no intervention. Fasting blood sugar (FBS) and blood sugar two hours post-prandial were checked in both groups at baseline and after two and four weeks. Data analysis was done using SPSS software (version 16) and chi-square, independent t-test, and Mann-Whitney tests at the significance level of p < 0.05. There was no significant difference in the mean FBS at baseline (109.31 ± 5.06 in the intervention and 109.03 ± 8.49 mg/dL in the control group, p = 0.904) and after two weeks after intervention (105.25 ± 5.92 in the intervention and 108.06 ± 8.75 mg/dL in the control group, p = 0.13), but the mean FBS after four weeks was significantly lower in the intervention (102.93 ± 7.75 mg/dL) compared to the control (107.90 ± 8.29 mg/dL) group (p = 0.019). The mean blood sugar two hours post-prandial was significantly lower in the intervention group compared to the control group after two (127.53 ± 8.03 and 143.68 ± 26.46 mg/dL, respectively, p = 0.006) and four weeks (127.09 ± 17.96 and 142.46 ± 27.06 mg/dL, respectively, p = 0.009). The results of the present study showed that barley savigh consumption could improve blood sugar regulation in pre-diabetic postmenopausal women.Trial registration: The present study was conducted as a randomized clinical trial. The study protocol was approved by the Iranian Registry of Clinical Trials (IRCT code 20200929048880N1). Registration date (25/10/2020).
更年期的激素变化使女性面临包括2型糖尿病在内的健康风险。因此，在这个年龄组预防糖尿病很重要。考虑到草药与化学药物相比副作用较少，本研究调查了食用大麦savigh对糖尿病前期绝经后女性血糖水平的影响。这项随机临床试验研究针对64名转诊至伊朗戈纳巴德市社区卫生中心的糖尿病前期绝经后女性进行。干预组（n = 32）每天食用60克大麦savigh（每餐饭前20克），对照组（n = 32）不进行干预。在基线以及两周和四周后，对两组进行空腹血糖（FBS）和餐后两小时血糖检查。使用SPSS软件（版本16）进行数据分析，并在p < 0.05的显著性水平下进行卡方检验、独立t检验和曼-惠特尼检验。干预组和对照组在基线时的平均空腹血糖无显著差异（干预组为109.31±5.06，对照组为109.03±8.49毫克/分升，p = 0.904），干预两周后也无显著差异（干预组为105.25±5.92，对照组为108.06±8.75毫克/分升，p = 0.13），但干预四周后的平均空腹血糖显著低于对照组（干预组为102.93±7.75毫克/分升，对照组为107.90±8.29毫克/分升，p = 0.019）。干预组餐后两小时的平均血糖在两周（分别为127.53±8.03和143.68±26.46毫克/分升，p = 0.006）和四周（分别为127.09±17.96和142.46±27.06毫克/分升，p = 0.009）后均显著低于对照组。本研究结果表明，食用大麦savigh可改善糖尿病前期绝经后女性的血糖调节。试验注册：本研究作为一项随机临床试验进行。研究方案已获伊朗临床试验注册中心批准（IRCT代码20200929048880N1）。注册日期（2020年10月25日）。
