大麦摄入对接受抗糖尿病治疗的日本2型糖尿病患者血糖控制的影响：一项前瞻性研究。

Effects of barley intake on glycemic control in Japanese patients with type 2 diabetes mellitus undergoing antidiabetic therapy: a prospective study.

作者信息

Osonoi Takeshi, Matsuoka Tsubasa, Ofuchi Kensuke, Katoh Makoto, Kobayashi Toshiki, Mochizuki Kazuki

机构信息

Naka Kinen Clinic, Naka, Ibaraki Japan.

Research and Development Department, Hakubaku Co. Ltd., Chuo, Yamanashi Japan.

出版信息

Diabetol Int. 2021 Oct 20;13(2):387-395. doi: 10.1007/s13340-021-00552-z. eCollection 2022 Apr.

DOI:10.1007/s13340-021-00552-z

PMID:35463852

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8980183/

Abstract

BACKGROUND

Barley reportedly reduces postprandial hyperglycemia in healthy individuals. However, its effects in patients with type 2 diabetes mellitus (T2DM) undergoing antidiabetic therapy remains unclear. This study aimed to clarify the effects of barley intake on postprandial hyperglycemia in T2DM patients who use metformin or acarbose.

METHODS

T2DM patients who were undergoing dietary therapy without medications (naive), with metformin, or with acarbose ( = 10/group) were recruited. They were instructed to eat white rice twice per day for 5 days, followed by barley-mixed rice twice per day for 6 or 7 days. Subsequently, blood glucose fluctuations in the interstitial fluid glucose were measured using a continuous glucose monitoring device. Meal tolerance tests were performed using test diets containing white rice and barley-mixed rice before and after the trial, respectively.

RESULTS

Postprandial hyperglycemia was lower in patients taking barley-mixed rice than in those taking white rice in each group. However, the AUC of blood glucose concentration in the acarbose-treated patients showed only a trend. Mean amplitude of glycemic excursions (MAGEs) decreased in patients who consumed barley-mixed rice. Additionally, although MAGEs in the naive decreased, it did not in the metformin- ( = 0.098) and acarbose-treated ( = 0.29) patients.

CONCLUSION

Barley-mixed rice lowers postprandial glucose concentrations in treatment-naive and metformin-treated T2DM patients, and shows a trend in acarbose-treated patients. Therefore, using barley-containing diets as dietary therapy may be useful in improving glycemic control in diabetes patients.

TRIAL REGISTRATION

UMIN000028623.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1007/s13340-021-00552-z.

摘要

背景

据报道，大麦可降低健康个体的餐后高血糖。然而，其对接受抗糖尿病治疗的2型糖尿病（T2DM）患者的影响尚不清楚。本研究旨在阐明摄入大麦对使用二甲双胍或阿卡波糖的T2DM患者餐后高血糖的影响。

方法

招募未接受药物治疗（初治）、接受二甲双胍治疗或接受阿卡波糖治疗的T2DM患者（每组10人）。指导他们连续5天每天吃两次白米饭，随后连续6或7天每天吃两次大麦混合米饭。随后，使用连续血糖监测设备测量组织间液葡萄糖中的血糖波动。分别在试验前后使用含白米饭和大麦混合米饭的试验饮食进行餐耐量试验。

结果

每组中，食用大麦混合米饭的患者餐后高血糖水平低于食用白米饭的患者。然而，阿卡波糖治疗组患者的血糖浓度曲线下面积（AUC）仅显示出一种趋势。食用大麦混合米饭的患者血糖波动平均幅度（MAGEs）降低。此外，尽管初治患者的MAGEs降低，但二甲双胍治疗组（P = 0.098）和阿卡波糖治疗组（P = 0.29）患者的MAGEs并未降低。