Sun Jiuyang, Tu Xinyu, Wang Shuwei, Wang Jie, Liang Jingxue, Liu Zhenguo, Song Lu
Department of neurology, Xinhua Hospital, Shanghai Jiao tong University School of Medicine, No.1665 Kongjiang Rd, Shanghai, China.
School of Medicine, Shanghai Jiao Tong University, No.227 Chongqing Rd (S), Shanghai, China.
BMC Geriatr. 2025 Jul 2;25(1):435. doi: 10.1186/s12877-025-05917-6.
Dementia is difficult to early diagnosis while intervention in late stage has limited effectiveness. Our study aimed to explore the associations between a potential risk factor, Life's Essential 8 (LE8), and cognitive performance informs of cognitive test score and subjective cognitive performance.
Data were obtained from NHANES 2011-2012 and 2013-2014. Cognitive test score was measured by summary Z-scores of three cognitive test. Subjective cognitive performance was defined by self-reported cognitive problem. Multivariable regression models and restricted cubic spline models were applied to evaluate the association between LE8 score and two cognitive performances. Subgroup analysis and ROC analysis were also conducted to compare the predictive abilities of LE8 on cognitive test score and subjective cognitive performance.
964 individuals were included in our multivariable regression model (adjusted for age, gender, race, family income, education and alcohol consumption). The LE8 score is positively associated with both cognitive test scores and subjective cognitive performance. The effect of LE8 score on both cognitive test score and subjective cognitive performance showed a trend of linearity. LE8 score and cognitive test score showed a J-shaped dose response relationship. ROC curve indicated that LE8 score predicted better on objective cognitive test score than subjective cognitive performance. Among all LE8 metrics, physical activity, nicotine exposure, blood lipids and blood glucose significantly associated with cognitive test score while only physical activity significantly associated with subjective cognitive performance. Subgroup analysis suggested that LE8 predicted subjective cognitive performance better in high-cognitive test score sub-population than in low-cognitive test score sub-population.
LE8 score had significant linear association with both cognitive test score and subjective cognitive performance. LE8 predicted cognitive test score better and the regression coefficient increase more significant as LE8 score increase than subjective cognitive performance.
Not applicable.
痴呆症难以早期诊断，而晚期干预效果有限。我们的研究旨在探讨一个潜在风险因素——生命必需的8要素（LE8）与认知表现（以认知测试分数和主观认知表现衡量）之间的关联。
数据来自2011 - 2012年和2013 - 2014年的美国国家健康与营养检查调查（NHANES）。认知测试分数通过三项认知测试的汇总Z分数来衡量。主观认知表现由自我报告的认知问题定义。应用多变量回归模型和受限立方样条模型来评估LE8分数与两种认知表现之间的关联。还进行了亚组分析和ROC分析，以比较LE8对认知测试分数和主观认知表现的预测能力。
964名个体纳入我们的多变量回归模型（对年龄、性别、种族、家庭收入、教育程度和饮酒情况进行了调整）。LE8分数与认知测试分数和主观认知表现均呈正相关。LE8分数对认知测试分数和主观认知表现的影响均呈线性趋势。LE8分数与认知测试分数呈J形剂量反应关系。ROC曲线表明，LE8分数对客观认知测试分数的预测优于主观认知表现。在所有LE8指标中，身体活动、尼古丁暴露、血脂和血糖与认知测试分数显著相关，而只有身体活动与主观认知表现显著相关。亚组分析表明，在高认知测试分数亚组中，LE8对主观认知表现的预测优于低认知测试分数亚组。
LE8分数与认知测试分数和主观认知表现均有显著的线性关联。LE8对认知测试分数的预测更好，且随着LE8分数的增加，回归系数的增加比主观认知表现更显著。
不适用。
