Li Keyi, Guo Chunhong, Yin Yishan, Zhu Zefeng
Department of Radiology, The First Hospital of Jiaxing and The Affiliated Hospital of Jiaxing University, 1882 Zhonghuan South Road, Jiaxing, Zhejiang Province, 314000, China.
The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
BMC Pediatr. 2025 Jul 2;25(1):512. doi: 10.1186/s12887-025-05871-7.
Dietary choline has been implicated in bone health, but its association with bone mineral density (BMD) in adolescents remains unclear. This study examines the relationship between dietary choline intake and BMD in adolescents aged 12-19 years.
This cross-sectional study included 2,531 adolescents from the NHANES 2005-2010 dataset, using weighted analyses to account for complex survey design. Dietary choline intake was assessed from two-day dietary recall data, and BMD for the lumbar spine and femur was measured by dual-energy X-ray absorptiometry (DXA). Multivariate regression models adjusted for relevant covariates. Subgroup analyses explored effect modifiers, and a sensitivity analysis with multiple imputation for missing covariates confirmed the stability of results.
Higher dietary choline intake was significantly associated with increased BMD in both the lumbar spine and femoral regions. For each 100 mg/day increase in choline intake, lumbar spine BMD increased by β = 6.75 (95% CI: 0.79-12.70, P = 0.028), and femoral BMD by β = 10.93 (95% CI: 3.58-18.27, P = 0.005). Participants in the highest choline intake tertile (T3) showed significantly higher BMD in the lumbar spine (β = 18.72, 95% CI: 1.84-35.60, P = 0.031) and femur (β = 28.33, 95% CI: 5.03-51,63, P = 0.020). The subgroup analyses indicated no significant interactions across subgroups, confirming the stability of the results. Additionally, sensitivity analyses conducted following multiple imputations of missing covariate data supported these findings.
Higher dietary choline intake is positively associated with BMD in adolescents, supporting the potential role of choline in bone health during this critical developmental period.
膳食胆碱与骨骼健康有关，但其与青少年骨矿物质密度（BMD）的关联仍不明确。本研究探讨了12至19岁青少年膳食胆碱摄入量与骨密度之间的关系。
这项横断面研究纳入了2005 - 2010年美国国家健康与营养检查调查（NHANES）数据集中的2531名青少年，采用加权分析以考虑复杂的调查设计。通过两日膳食回忆数据评估膳食胆碱摄入量，采用双能X线吸收法（DXA）测量腰椎和股骨的骨密度。多变量回归模型对相关协变量进行了调整。亚组分析探索了效应修饰因素，对缺失协变量进行多重填补的敏感性分析证实了结果的稳定性。
较高的膳食胆碱摄入量与腰椎和股骨区域骨密度增加显著相关。胆碱摄入量每增加100毫克/天，腰椎骨密度增加β = 6.75（95%置信区间：0.79 - 12.70，P = 0.028），股骨骨密度增加β = 10.93（95%置信区间：3.58 - 18.27，P = 0.005）。胆碱摄入量最高三分位数（T3）的参与者在腰椎（β = 18.72，95%置信区间：1.84 - 35.60，P = 0.031）和股骨（β = 28.33，95%置信区间：5.03 - 51.63，P = 0.020）的骨密度显著更高。亚组分析表明各亚组间无显著交互作用，证实了结果的稳定性。此外，对缺失协变量数据进行多重填补后进行的敏感性分析支持了这些发现。
较高的膳食胆碱摄入量与青少年骨密度呈正相关，支持了胆碱在这一关键发育阶段对骨骼健康的潜在作用。
