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阿尔茨海默病患者脑脊液中的tau蛋白播种活性可预测短期认知衰退。

Tau seeding activity in the cerebrospinal fluid of Alzheimer disease patients predicts short-term cognitive decline.

作者信息

Houzé Ludivine, Dhenain Marc, Lam Suzanne, Petit Fanny, Haïk Stéphane, Mouton-Liger François, Hugon Jacques, Dam Julie, Paquet Claire, Jockers Ralf, Cecon Erika

机构信息

Université Paris Cité, CNRS, Inserm, Institut Cochin, Paris, F-75014, France.

Laboratoire des Maladies Neurodégénératives, Université Paris-Saclay, CEA, CNRS, Fontenay-aux-Roses, France.

出版信息

Alzheimers Res Ther. 2025 Jul 2;17(1):145. doi: 10.1186/s13195-025-01792-w.

DOI:10.1186/s13195-025-01792-w
PMID:40605084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12220128/
Abstract

BACKGROUND

Alzheimer disease (AD) clinical progression is highly heterogeneous, making its prediction essential for the development of effective therapies. The advancement of cognitive decline in AD is tightly linked to the spread of pathological tau protein aggregates in the brain, through tau seeding properties.

METHODS

We developed a cellular biosensor to measure tau seeding activity from cerebrospinal fluid (CSF) and human brain lysates. Longitudinal analysis of cognitive function was correlated with biosensor response.

RESULTS

Individuals with CSF exhibiting high or intermediate seeding activity experienced more rapid cognitive decline compared to those with low seeding. High tau seeding was associated with total and phosphorylated tau biomarkers in AD. The biosensor also predicts the potential of human AD brain lysates to induce tau aggregation upon experimental transmission in animal models.

CONCLUSIONS

These results suggest that seeding activity might be a relevant biomarker to forecast AD pathogenicity and clinical progression.

摘要

背景

阿尔茨海默病（AD）的临床进展具有高度异质性，因此对其进行预测对于开发有效的治疗方法至关重要。AD认知功能衰退的进展与病理性tau蛋白聚集体在大脑中的传播紧密相关，这是通过tau种子特性实现的。

方法

我们开发了一种细胞生物传感器，用于测量脑脊液（CSF）和人脑裂解物中的tau种子活性。认知功能的纵向分析与生物传感器的反应相关。

结果

与低种子活性的个体相比，脑脊液表现出高或中等种子活性的个体经历了更快的认知衰退。高tau种子活性与AD中的总tau和磷酸化tau生物标志物相关。该生物传感器还预测了人类AD脑裂解物在动物模型中进行实验性传播时诱导tau聚集的潜力。

结论

这些结果表明，种子活性可能是预测AD致病性和临床进展的相关生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c0/12220128/200384713760/13195_2025_1792_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c0/12220128/ad8e7e4dc7c0/13195_2025_1792_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c0/12220128/dddb9e61dfce/13195_2025_1792_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c0/12220128/c21850b60d9d/13195_2025_1792_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c0/12220128/200384713760/13195_2025_1792_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c0/12220128/ad8e7e4dc7c0/13195_2025_1792_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c0/12220128/dddb9e61dfce/13195_2025_1792_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c0/12220128/c21850b60d9d/13195_2025_1792_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c0/12220128/200384713760/13195_2025_1792_Fig3_HTML.jpg

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本文引用的文献

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Nat Aging. 2024 Apr;4(4):453-463. doi: 10.1038/s43587-024-00611-5. Epub 2024 Apr 19.
2
Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer's disease brain.Tau 种子扩增检测揭示了阿尔茨海默病脑中 tau 种与病理形式之间的关系。
Acta Neuropathol Commun. 2023 Nov 14;11(1):181. doi: 10.1186/s40478-023-01676-w.
3
Cognitive effects of Lewy body pathology in clinically unimpaired individuals.
路易体病在临床无明显障碍个体中的认知影响。
Nat Med. 2023 Aug;29(8):1971-1978. doi: 10.1038/s41591-023-02450-0. Epub 2023 Jul 18.
4
A seeding-based neuronal model of tau aggregation for use in drug discovery.用于药物发现的基于 Tau 聚集的种系神经元模型。
PLoS One. 2023 Apr 4;18(4):e0283941. doi: 10.1371/journal.pone.0283941. eCollection 2023.
5
Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells.新型 tau 生物传感器谱，用于监测活细胞中病理性 tau 转化和种子活性。
Elife. 2023 Mar 14;12:e78360. doi: 10.7554/eLife.78360.
6
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J Gerontol A Biol Sci Med Sci. 2023 Mar 30;78(4):645-652. doi: 10.1093/gerona/glac234.
7
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P-tau235: a novel biomarker for staging preclinical Alzheimer's disease.P-tau235：一种用于临床前阿尔茨海默病分期的新型生物标志物。
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