Wang Lei, Zheng Guimin, Jia Xiuchuan, Chen Yingmin
Department of Radiology, Hebei General Hospital, No.348 Heping West Road, Shijiazhuang City, Hebei Province, 050051, China.
Department of Rheumatology, Hebei General Hospital, Shijiazhuang City, Hebei Province, China.
Adv Rheumatol. 2025 Jul 3;65(1):30. doi: 10.1186/s42358-025-00463-6.
Cognitive impairment (CI) is a significant problem in systemic lupus erythematosus (SLE) patients. In recent years, total cerebral small vessel disease (CSVD) burden scores have had substantial value in predicting cognitive impairment. However, its application in treating concurrent cognitive impairment in SLE patients is unclear. To explore the relationship between total CSVD burden scores and cognitive dysfunction in SLE patients and to analyze its predictive value.
The Montreal Cognitive Assessment (MoCA) score was used to evaluate the cognitive function of 50 patients with SLE, and the total load score of patients with CSVD was analyzed via magnetic resonance imaging (MRI). Multivariate regression was used to evaluate the relationship between total CSVD burden scores and cognitive dysfunction, and the predictive value of total CSVD burden scores was assessed.
Multivariate logistic regression analysis revealed that years of education (OR = 0.975, 95% CI [0.952-0.998], P = 0.035), neuropsychiatric systemic lupus erythematosus (NPSLE) (OR = 4.152, 95% CI [2.158-7.990], P < 0.001), and the CSVD total burden score (OR = 3.884, 95% CI [0.840-0.928], P < 0.001) were independently associated with cognitive impairment in SLE patients. The results of the ROC curve analysis revealed that the area under the curve (AUC) of the CSVD total burden score for the prediction of cognitive impairment in SLE patients was 0.885.
Years of education, NPSLE score, and total CSVD burden score are closely related to the occurrence of cognitive impairment in SLE patients. In particular, the total CSVD burden score is beneficial for the prediction of cognitive impairment.
Not applicable.
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认知障碍（CI）是系统性红斑狼疮（SLE）患者的一个重要问题。近年来，全脑小血管疾病（CSVD）负担评分在预测认知障碍方面具有重要价值。然而，其在治疗SLE患者并发认知障碍中的应用尚不清楚。旨在探讨SLE患者CSVD总负担评分与认知功能障碍之间的关系，并分析其预测价值。
采用蒙特利尔认知评估（MoCA）评分评估50例SLE患者的认知功能，并通过磁共振成像（MRI）分析CSVD患者的总负荷评分。采用多因素回归评估CSVD总负担评分与认知功能障碍之间的关系，并评估CSVD总负担评分的预测价值。
多因素logistic回归分析显示，受教育年限（OR = 0.975，95%CI [0.952 - 0.998]，P = 0.035）、神经精神性系统性红斑狼疮（NPSLE）（OR = 4.152，95%CI [2.158 - 7.990]，P < 0.001）和CSVD总负担评分（OR = 3.884，95%CI [0.840 - 0.928]，P < 0.001）与SLE患者的认知障碍独立相关。ROC曲线分析结果显示，CSVD总负担评分预测SLE患者认知障碍的曲线下面积（AUC）为0.885。
受教育年限、NPSLE评分和CSVD总负担评分与SLE患者认知障碍的发生密切相关。特别是，CSVD总负担评分有助于预测认知障碍。
不适用。
不适用。
