[正常条件下及受两种杀虫剂（杀虫脒和狄氏剂）中毒后飞蝗大脑的单胺氧化酶活性]
[Monoamine oxidase activity of the brain of Locusta migratoria in normal conditions and after intoxication by two insecticides: chlordimeform and dieldrin].
作者信息
Gripois D, Moreteau B, Ramade F
出版信息
C R Acad Hebd Seances Acad Sci D. 1977 Mar 21;284(12):1079-82.
Our investigations have shown up an MAO activity in locust brain, by the use of a radio-isotopic method, as much at larval as at adult stage. This MAO activity is in a sample of 34,3 dpm/mg of brain tissue (wet weight). Investigations have also been undertaken on effects of dieldrin and chlordimeform poisoning on this MAO activity. Even at sublethal dosages, chlordimeform causes a significant inhibition of MAO activity in vivo. This finding is in accordance with Beeman and Matsumura's work in vitro. Moreover, acute poisoning by dieldrin produces more than 60% of inhibition of MAO, 3 hours after administration of 115 microng of this insecticide by injection in the hoemocelian cavity.
我们的研究通过放射性同位素方法显示，在蝗虫大脑中，幼虫期和成虫期均存在单胺氧化酶（MAO）活性。该MAO活性在每毫克脑组织（湿重）的样本中为34.3每分钟衰变数（dpm）。我们还研究了狄氏剂和杀虫脒中毒对这种MAO活性的影响。即使在亚致死剂量下，杀虫脒在体内也会导致MAO活性显著抑制。这一发现与比曼和松村的体外研究结果一致。此外，通过向血腔注射115微克这种杀虫剂3小时后，狄氏剂急性中毒会使MAO活性受到超过60%的抑制。
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