[正常条件下及受两种杀虫剂（杀虫脒和狄氏剂）中毒后飞蝗大脑的单胺氧化酶活性]

[Monoamine oxidase activity of the brain of Locusta migratoria in normal conditions and after intoxication by two insecticides: chlordimeform and dieldrin].

作者信息

Gripois D, Moreteau B, Ramade F

出版信息

C R Acad Hebd Seances Acad Sci D. 1977 Mar 21;284(12):1079-82.

Abstract

Our investigations have shown up an MAO activity in locust brain, by the use of a radio-isotopic method, as much at larval as at adult stage. This MAO activity is in a sample of 34,3 dpm/mg of brain tissue (wet weight). Investigations have also been undertaken on effects of dieldrin and chlordimeform poisoning on this MAO activity. Even at sublethal dosages, chlordimeform causes a significant inhibition of MAO activity in vivo. This finding is in accordance with Beeman and Matsumura's work in vitro. Moreover, acute poisoning by dieldrin produces more than 60% of inhibition of MAO, 3 hours after administration of 115 microng of this insecticide by injection in the hoemocelian cavity.

摘要

我们的研究通过放射性同位素方法显示，在蝗虫大脑中，幼虫期和成虫期均存在单胺氧化酶（MAO）活性。该MAO活性在每毫克脑组织（湿重）的样本中为34.3每分钟衰变数（dpm）。我们还研究了狄氏剂和杀虫脒中毒对这种MAO活性的影响。即使在亚致死剂量下，杀虫脒在体内也会导致MAO活性显著抑制。这一发现与比曼和松村的体外研究结果一致。此外，通过向血腔注射115微克这种杀虫剂3小时后，狄氏剂急性中毒会使MAO活性受到超过60%的抑制。

相似文献

1

[Monoamine oxidase activity of the brain of Locusta migratoria in normal conditions and after intoxication by two insecticides: chlordimeform and dieldrin].[正常条件下及受两种杀虫剂（杀虫脒和狄氏剂）中毒后飞蝗大脑的单胺氧化酶活性]

C R Acad Hebd Seances Acad Sci D. 1977 Mar 21;284(12):1079-82.

2

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3

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MAO inhibition, an unlikely mode of action for chlordimeform.单胺氧化酶抑制作用，这是杀虫脒不太可能的作用方式。

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6

[Enzymatic N-acetylation of tryptamine by brain homogenates of Locusta migratoria before and after intoxication by chlordimeform or lindane (author's transl)].在受到杀虫脒或林丹中毒前后，飞蝗脑匀浆对色胺的酶促N-乙酰化作用（作者译）

Experientia. 1979 Oct 15;35(10):1357-9. doi: 10.1007/BF01964006.

7

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Mode of action of formamidine pesticides: an evaluation of monoamine oxidase as the target.甲脒类杀虫剂的作用模式：以单胺氧化酶作为靶点的评估

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Action of formamidine pesticides on octopamine receptors.脒基农药对章鱼胺受体的作用。

Nature. 1980 Sep 4;287(5777):60-2. doi: 10.1038/287060a0.

10

Effect of chlordimeform and clonidine on the turnover of P-octopamine in rat hypothalamus and striatum.杀虫脒和可乐定对大鼠下丘脑和纹状体中对-章鱼胺周转的影响。

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引用本文的文献

1

[Enzymatic N-acetylation of tryptamine by brain homogenates of Locusta migratoria before and after intoxication by chlordimeform or lindane (author's transl)].在受到杀虫脒或林丹中毒前后，飞蝗脑匀浆对色胺的酶促N-乙酰化作用（作者译）

Experientia. 1979 Oct 15;35(10):1357-9. doi: 10.1007/BF01964006.

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