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在受到杀虫脒或林丹中毒前后,飞蝗脑匀浆对色胺的酶促N-乙酰化作用(作者译)

[Enzymatic N-acetylation of tryptamine by brain homogenates of Locusta migratoria before and after intoxication by chlordimeform or lindane (author's transl)].

作者信息

Allais J P, Gripois D, Moreteau B, Ramade F

出版信息

Experientia. 1979 Oct 15;35(10):1357-9. doi: 10.1007/BF01964006.

Abstract

Brain homogenates of Locusta migratoria are found to possess enzyme capable of catalyzing the N-acetylation of tryptamine. A main product of the enzymatic reaction is isolated and identified as N-acetyltryptamine by chromatography analyse. Both insecticides, chlordimeform and lindane, inhibit enzyme activity. A direct correlation between the degree of intoxication and acetylation of tryptamine is described.

摘要

人们发现,飞蝗的脑匀浆含有能够催化色胺N - 乙酰化反应的酶。通过色谱分析分离并鉴定出酶促反应的主要产物为N - 乙酰色胺。杀虫剂杀虫脒和林丹均能抑制该酶的活性。文中描述了中毒程度与色胺乙酰化之间的直接关联。

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