Carrigan D R
Virology. 1985 Jul 30;144(2):337-50. doi: 10.1016/0042-6822(85)90276-4.
A subacute sclerosing panencephalitis strain of measles virus was found to be composed of two viral variants distinguishable by their cytopathic effects in Vero cells. One of the variants was similar to defective cell-associated measles virus strains, whereas the other was highly productive of viral progeny but did not induce cell fusion. Cloning of the variants by an agarose plaque procedure revealed a consistent and rapid interconversion of the variants into one another. While the mechanism of this interconversion remains unknown, analysis of the expression of viral antigens by the variants using indirect immunofluorescence with monoclonal antibodies specific for measles structural antigens suggested that the interconversion involved modulation of the expression of the viral matrix or M antigen.
发现一株亚急性硬化性全脑炎麻疹病毒由两种病毒变体组成，可通过它们在Vero细胞中的细胞病变效应加以区分。其中一种变体类似于缺陷性细胞相关麻疹病毒株，而另一种则能高效产生病毒后代，但不诱导细胞融合。通过琼脂糖噬斑法对这些变体进行克隆，结果显示这些变体可一致且快速地相互转化。虽然这种相互转化的机制尚不清楚，但使用针对麻疹结构抗原的单克隆抗体通过间接免疫荧光对这些变体的病毒抗原表达进行分析表明，这种相互转化涉及病毒基质或M抗原表达的调节。
