Carrigan D R
Virology. 1986 Jan 30;148(2):349-59. doi: 10.1016/0042-6822(86)90331-4.
A subacute sclerosing panencephalitis (SSPE) strain of measles virus has been previously shown to be composed of two interrelated but separable viral variants. One of these, the syncytiagenic or S variant, resembles defective, cell-associated strains of measles virus; while the other, the round cell inducing or RC variant, induces a highly productive infection in cell culture. It is now reported that the S variant is more neurovirulent in newborn hamsters than the RC variant and that viral replication in infected CNS tissues occurs in two phases. Early in the infection cell-free virus, composed primarily of the RC variant, is produced. Later, coincident with the appearance of antiviral antibody, cell-free virus rapidly disappears, leaving behind only cell-associated virus which resembles the S variant. Quantification of viral antigen expression in the infected tissues suggests that this change in the state of infection is not associated with antigenic modulation, but rather is the result of preferential elimination of RC variant infected cells.
先前已表明，亚急性硬化性全脑炎（SSPE）麻疹病毒株由两种相互关联但可分离的病毒变体组成。其中一种，即多核细胞形成性或S变体，类似于有缺陷的、细胞相关的麻疹病毒株；而另一种，即圆细胞诱导性或RC变体，在细胞培养中可引发高效感染。现在有报道称，S变体在新生仓鼠中比RC变体的神经毒性更强，且感染的中枢神经系统组织中的病毒复制分两个阶段进行。在感染早期，主要由RC变体组成的游离病毒产生。后来，与抗病毒抗体的出现同时，游离病毒迅速消失，仅留下类似于S变体的细胞相关病毒。对感染组织中病毒抗原表达的定量分析表明，感染状态的这种变化与抗原调节无关，而是优先清除RC变体感染细胞的结果。
