Li Fang, Lu Mengge, Xu Bo, Xiang Zheng, Zhang Yuan, Cao Boran, Li Xuewei, Wu Yanan, Zheng Rongrong, Cai Qin, Shen Jun, Xin Pengfei, Xiao Lianbo, Bian Yanqin
Department of Gastroenterology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shanghai Guanghua Hospital of Integrative Medicine, Shanghai, China.
Front Med (Lausanne). 2025 Jun 18;12:1553194. doi: 10.3389/fmed.2025.1553194. eCollection 2025.
To investigate the factors associated with the recurrence of colorectal polyps.
Data on polyp recurrence and related factors, including gender, age, BMI, family history, smoking history, alcohol consumption history, gallbladder disease history, food allergy, polyp size, number, and pathological classification, (Hp) infection, parathyroid hormone, gastrin, and blood lipid levels, were collected as exposure factors. Polyp recurrence was used as the outcome measure. Logistic regression analysis was used to evaluate risk and protective factors for colorectal polyp recurrence. The diagnostic performance of the identified risk factor model was assessed using ROC curve analysis.
Among the 318 patients, 170 experienced polyp recurrence, while 148 did not. Logistic regression analysis revealed that gender (OR = 1.927, 95% CI = 1.134-3.276, = 0.015), age (OR = 3.228, 95% CI = 1.846-5.647, < 0.001), history of gallbladder disease (OR = 2.011, 95% CI = 1.147-3.523, = 0.015), food allergy (OR = 2.246, 95% CI = 1.211-4.545, = 0.012), pathological classification (OR = 5.023, 95% CI = 2.932-8.606, < 0.001), and Hp infection (OR = 1.970, 95% CI = 1.171-3.312, = 0.011) were positively associated with polyp recurrence. Conversely, polyp size (OR = 0.324, 95% CI = 0.127-0.827, = 0.018) was negatively associated with recurrence. Logit(p) = -2.459 + 0.656 × Gender + 1.172 × Age 61-80 years + 0.698 × Gallbladder Disease + 0.853 × Food Allergy-1.127 × Polyp Size + 1.164 × Pathological Classification + 0.678 × Hp Infection. The risk prediction model can be used to predict post-surgical recurrence of colorectal polyps with a sensitivity of 0.88 and specificity of 0.56. The cutoff value for this odds prediction model is 0.44.
Elderly (61-80 years old) male patients with adenomatous colorectal cancer and the history of (Hp) infection, gallbladder disease and food allergy have higher odds to experience recurrence after surgical resection. On the contrary, those patients with a larger polyp size (≥2 cm) are less odds to experience recurrence. Patients with a risk prediction model value greater than or equal to 0.44 have increased odds to experience postoperative recurrence.
探讨结直肠息肉复发的相关因素。
收集息肉复发及相关因素的数据，包括性别、年龄、体重指数、家族史、吸烟史、饮酒史、胆囊疾病史、食物过敏、息肉大小、数量及病理分类、幽门螺杆菌（Hp）感染、甲状旁腺激素、胃泌素和血脂水平等作为暴露因素。以息肉复发作为结局指标。采用Logistic回归分析评估结直肠息肉复发的危险因素和保护因素。使用受试者工作特征（ROC）曲线分析评估所确定危险因素模型的诊断效能。
318例患者中，170例息肉复发，148例未复发。Logistic回归分析显示，性别（比值比[OR]=1.927，95%可信区间[CI]=1.134 - 3.276，P=0.015）、年龄（OR = 3.228，95%CI = 1.846 - 5.647，P<0.001）、胆囊疾病史（OR = 2.011，95%CI = 1.147 - 3.523，P=0.015）、食物过敏（OR = 2.246，95%CI = 1.211 - 4.545，P=0.012）、病理分类（OR = 5.023，95%CI = 2.932 - 8.606，P<0.001）及Hp感染（OR = 1.970，95%CI = 1.171 - 3.312，P=0.011）与息肉复发呈正相关。相反，息肉大小（OR = 0.324，95%CI = 0.127 - 0.827，P=0.018）与复发呈负相关。Logit(p)= -2.459 + 0.656×性别 + 1.172×61 - 80岁年龄 + 0.698×胆囊疾病 + 0.853×食物过敏 - 1.127×息肉大小 + 1.164×病理分类 + 0.678×Hp感染。该风险预测模型可用于预测结直肠息肉术后复发，灵敏度为0.88，特异度为0.56。此比值比预测模型的截断值为0.44。
年龄在61 - 80岁的老年男性患者，患有腺瘤性结直肠癌且有Hp感染、胆囊疾病和食物过敏史，手术切除后复发几率较高。相反，息肉较大（≥2 cm）的患者复发几率较低。风险预测模型值大于或等于0.44的患者术后复发几率增加。
