Klapow Maxwell, Seeff Misha, Adam Maya, Greuel Merlin, Hoffman Daniel, Rogge Jessica R, Gordon Andrew, Bärnighausen Till, Amsalem Doron
Department of Experimental Psychology, University of Oxford, Oxford, UK.
United World College Maastricht, Maastricht, the Netherlands.
Addict Behav Rep. 2025 Jun 17;22:100622. doi: 10.1016/j.abrep.2025.100622. eCollection 2025 Dec.
Public stigma towards people with addiction negatively impacts help-seeking, treatment and recovery. This pilot study tested the feasibility of conducting a large-scale, online trial to measure the effect of a short, animated storytelling (SAS) stigma reduction video, with and without soundtrack, on addiction stigma, optimism, warmth towards people with addiction, and hopefulness at two timepoints (immediately post-exposure and 14 days later).
We used a parallel group, three-arm randomized controlled trial (RCT).
We conducted this fully online study on the Prolific Academic research platform (participant recruitment) and the Qualtrics survey platform (data collection).
We recruited 631 English-speaking adult participants, aged 18-49, residing in the United States.
Intervention group A received the SAS video intervention. Intervention group B group received the SAS video intervention without sound. The control group received written information about global addiction prevalence, estimated to be time-equivalent with the video interventions.
We measured participant retention rate at the two-week follow-up to determine the feasibility of conducting the definitive trial. Our co-primary outcomes were addiction stigma, optimism, warmth towards people with addiction and hopefulness, measured using an abbreviated 18-item version of the Attribution Questionnaire (AQ-18), the Brief García's Interactive Optimism Scale (BIOS-G), a stigma thermometer and a visual analogue scale (VAS). We used repeated-measures ANOVA to assess group-by-time interactions and compared changes from baseline to post-intervention. Participants completed follow-up surveys 14 days post-intervention.
The retention rate from baseline to follow-up was 88.0 %. Exposure to both the video with sound and without sound resulted in significant positive changes compared to the control group, for pity [F (4,1046) = 3.26, η = 0.012, p = 0.011], willingness to help [F (4,1046) = 8.48, η = 0.031, p < 0.001], dangerousness [F (4,1046) = 2.95, η = 0.011, p = 0.019], avoidance [F (4,1046) = 4.25, η = 0.016, p = 0.002], as well as optimism [F (2,595) = 7.7, η = 0.014, p < 0.001], warmth toward people with addiction [F (2,594) = 6.5, η = 0.014, p = 0.002], and hopefulness [F (2,594) = 5.4, η = 0.013, p = 0.005]. No effects were observed for fear or blame stigma sub-scales. These effects were no longer visible at follow-up in this pilot sample. No significant differences were observed between the video with sound and the video without sound.
This pilot study demonstrates the feasibility of proceeding with our registered, largescale, multi-country, online RCT. The significant effect observed in a relatively small pilot population, after a single exposure to this 2.5 min SAS intervention aimed at reducing addiction stigma, was unanticipated and is worthy of highlighting. A larger sample size will adequately power the full trial to detect both immediate effects and their potential durability over time, in various global settings.
公众对成瘾者的污名化对寻求帮助、治疗和康复产生负面影响。这项试点研究测试了开展一项大规模在线试验的可行性,该试验旨在测量一段简短的动画故事讲述(SAS)污名减少视频(有无配乐)对成瘾污名、乐观情绪、对成瘾者的温暖态度以及两个时间点(暴露后立即和14天后)的希望感的影响。
我们采用了平行组、三臂随机对照试验(RCT)。
我们在Prolific Academic研究平台(参与者招募)和Qualtrics调查平台(数据收集)上进行了这项完全在线的研究。
我们招募了631名年龄在18 - 49岁、居住在美国且讲英语的成年参与者。
干预组A接受SAS视频干预。干预组B接受无声音的SAS视频干预。对照组接受关于全球成瘾流行率的书面信息,估计其时长与视频干预相当。
我们在两周随访时测量参与者保留率,以确定进行确定性试验的可行性。我们的共同主要结局指标是成瘾污名、乐观情绪、对成瘾者的温暖态度和希望感,使用归因问卷(AQ - 18)的简化18项版本、简短的加西亚互动乐观量表(BIOS - G)、污名温度计和视觉模拟量表(VAS)进行测量。我们使用重复测量方差分析来评估组间时间交互作用,并比较从基线到干预后的变化。参与者在干预后14天完成随访调查。
从基线到随访的保留率为88.0%。与对照组相比,接触有声音和无声音的视频均导致在怜悯感[F(4,1046)=3.26,η = 0.012,p = 0.011]、帮助意愿[F(4,1046)=8.48,η = 0.031,p < 0.001]、危险性[F(4,1046)=2.95,η = 0.011,p = 0.019]、回避[F(4,1046)=4.25,η = 0.016,p = 0.002],以及乐观情绪[F(2,595)=7.7,η = 0.014,p < 0.001]、对成瘾者的温暖态度[F(2,594)=6.5,η = 0.014,p = 0.002]和希望感[F(2,594)=5.4,η = 0.013,p = 0.005]方面出现显著的积极变化。在恐惧或责备污名子量表上未观察到影响。在这个试点样本的随访中,这些影响不再明显。有声音视频和无声音视频之间未观察到显著差异。
这项试点研究证明了推进我们已注册的大规模、多国在线随机对照试验的可行性。在相对较小的试点人群中,单次接触这个旨在减少成瘾污名的2.5分钟SAS干预后观察到显著效果,这是出乎意料的,值得强调。更大的样本量将为全面试验提供足够的效力,以检测在各种全球环境下的即时效果及其随时间的潜在持续性。