Effects of dietary glycerol, vitamin C and niacinamide supplementation on liver of growing-finishing pigs.

The influence of supplementing glycerol, vitamin C and niacinamide on the liver of growing-finishing pigs has not yet been examined. This study investigated the effect of 10% glycerol, 0.06% vitamin C and 0.05% niacinamide supplementation at single or combination on liver of growing-finishing pigs. Compared with pigs supplemented with 0% glycerol, 0% vitamin C and 0% niacinamide, pigs supplemented only with 10% glycerol had higher ( < 0.05) TNF- concentration, partially hepatic steatosis, higher ( < 0.05) relative abundances of , , , , and , lower ( < 0.05) solute carrier family 7 member 11 () expression in liver tissue. However, pigs offered the diet with a mixture of 0.06% vitamin C and 0.05% niacinamide had higher ( < 0.05) relative abundance of and expression of , lower ( < 0.05) relative abundances of and in liver tissue. Supplementation of 10% glycerol, 0.06% vitamin C and 0.05% niacinamide simultaneously to pigs increased ( < 0.05) the ferrous ion level, the relative abundances of , and , the expressions of gene Cryptochrome-1() and , but decreased ( < 0.05) the expressions of gene C-reactive protein () and galactokinase 1 () in liver tissue. Supplementation with 0.06% vitamin C and 0.05% niacinamide can alleviate the damage in liver of pigs fed a diet containing 10% glycerol.