Liao Yi-Hung, Mündel Toby, Chen Ying-Chu, Tsai Shiow-Chwen, Wu Kuo-Cheng, Chen Mu-Tsung, Lee Li-Chen, Su Chih-Peng, Chang Yu-Kai, Chen Chung-Yu
Department of Exercise and Health Science, National Taipei University of Nursing and Health Sciences, Taipei City, Taiwan.
Department of Kinesiology, Brock University, St. Catharines, ON, Canada.
Eur J Appl Physiol. 2025 Jul 3. doi: 10.1007/s00421-025-05877-0.
This study investigated the effects of two different combined exercise modalities on executive function in healthy adults and observed the associations of potential biomarkers (i.e., brain-derived neurotrophic factor, BDNF; human growth hormone, HGH; insulin-like growth factor-1, IGF-1; and cortisol) on cognitive performance.
Twelve young healthy male adults were recruited and assigned to the following three experimental interventions in a randomized crossover manner: sitting control (SC), resistance exercise plus continuous aerobic exercise (RA) and resistance exercise plus intermittent aerobic exercise (RI). Stroop Color and Word Test (SCWT) and blood collection were conducted before and immediately after each intervention.
The results showed that both acute combined exercise trials significantly reduced SCWT-incongruent response time compared to the SC trial (RA: p = .015, RI: p = .014). The serum BDNF and HGH levels were significantly increased in both RA (BDNF: p < .0001, HGH: p = .004) and RI (BDNF: p = .013, HGH: p = .007) trials, and the serum IGF-1 level was significantly increased in the RI trial (p = .008). The changes in SCWT-incongruent response time were significantly associated with the changes in blood lactate (r = - 0.622, p < .0001) and RPE (r = - 0.364, p = .029) following the interventions.
Our findings indicate the beneficial effects of two different combined exercise modalities on executive function in these young healthy males that could be related to an increase in brain energy supply and arousal status.
IRB-2021-011.
本研究调查了两种不同的联合运动方式对健康成年人执行功能的影响，并观察了潜在生物标志物（即脑源性神经营养因子，BDNF；人生长激素，HGH；胰岛素样生长因子-1，IGF-1；和皮质醇）与认知表现之间的关联。
招募了12名年轻健康男性成年人，并以随机交叉的方式将他们分配到以下三种实验干预中：静坐对照组（SC）、抗阻运动加持续有氧运动（RA）和抗阻运动加间歇有氧运动（RI）。在每次干预前和干预后立即进行斯特鲁普颜色和文字测试（SCWT）以及血液采集。
结果表明，与SC试验相比，两种急性联合运动试验均显著缩短了SCWT-不一致反应时间（RA：p = 0.015，RI：p = 0.014）。在RA（BDNF：p < 0.0001，HGH：p = 0.004）和RI（BDNF：p = 0.013，HGH：p = 0.007）试验中，血清BDNF和HGH水平均显著升高，在RI试验中血清IGF-1水平显著升高（p = 0.008）。干预后，SCWT-不一致反应时间的变化与血乳酸变化（r = -0.622，p < 0.0001）和主观用力程度（r = -0.364，p = 0.029）显著相关。
我们的研究结果表明，两种不同的联合运动方式对这些年轻健康男性的执行功能具有有益影响，这可能与大脑能量供应和唤醒状态的增加有关。
IRB-2021-011。
