Wang An, Ma Haoyu, Bai Long, Wu Yanan, Xu Mengya, Zhang Yang, Islam Mobarakol, Ren Hongliang
Department of Electronic Engineering, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China; CUHK Shenzhen Research Institute, Shenzhen, China.
Department of Electronic Engineering, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
Comput Med Imaging Graph. 2025 Sep;124:102591. doi: 10.1016/j.compmedimag.2025.102591. Epub 2025 Jul 1.
Recent advancements in deep learning techniques have contributed to developing improved polyp segmentation methods, thereby aiding in the diagnosis of colorectal cancer and facilitating automated surgery like endoscopic submucosal dissection (ESD). However, the scarcity of well-annotated data poses challenges by increasing the annotation burden and diminishing the performance of fully-supervised learning approaches. Additionally, distribution shifts due to variations among patients and medical centers require the model to generalize well during testing. To address these concerns, we present PedSemiSeg, a pedagogy-inspired semi-supervised learning framework designed to enhance polyp segmentation performance with limited labeled training data. In particular, we take inspiration from the pedagogy used in real-world educational settings, where teacher feedback and peer tutoring are both crucial in influencing the overall learning outcome. Expanding upon this concept, our approach involves supervising the outputs of the strongly augmented input (the students) using the pseudo and complementary labels crafted from the output of the weakly augmented input (the teacher) in both positive and negative learning manners. Additionally, we introduce reciprocal peer tutoring among the students, guided by respective prediction entropy. With these holistic learning processes, we aim to achieve consistent predictions for various versions of the same input and maximize the utilization of the abundant unlabeled data. Experimental results on two public datasets demonstrate the superiority of our method in polyp segmentation across various labeled data ratios. Furthermore, our approach exhibits excellent generalization capabilities on external unseen multi-center datasets, highlighting its broader clinical significance in practical applications during deployment.
深度学习技术的最新进展推动了改进的息肉分割方法的发展,从而有助于结直肠癌的诊断,并促进诸如内镜黏膜下剥离术(ESD)等自动化手术。然而,标注良好的数据稀缺,增加了标注负担并降低了全监督学习方法的性能,从而带来了挑战。此外,由于患者和医疗中心之间的差异导致的分布变化要求模型在测试期间具有良好的泛化能力。为了解决这些问题,我们提出了PedSemiSeg,这是一种受教学法启发的半监督学习框架,旨在利用有限的标注训练数据提高息肉分割性能。具体而言,我们从现实世界教育环境中使用的教学法中汲取灵感,在这种环境中,教师反馈和同伴辅导对于影响整体学习成果都至关重要。在此概念的基础上进行扩展,我们的方法包括以正向和负向学习方式,使用从弱增强输入(教师)的输出中精心制作的伪标签和互补标签来监督强增强输入(学生)的输出。此外,我们在学生之间引入了以各自预测熵为指导的相互同伴辅导。通过这些整体学习过程,我们旨在对同一输入的各种版本实现一致的预测,并最大限度地利用丰富的未标注数据。在两个公共数据集上的实验结果证明了我们的方法在各种标注数据比例下进行息肉分割的优越性。此外,我们的方法在外部未见的多中心数据集上表现出出色的泛化能力,突出了其在部署期间实际应用中更广泛的临床意义。