Strøm J, Häggmark S, Madsen P S, Reiz S, Bredgaard Sørensen M
Acta Anaesthesiol Scand. 1985 Aug;29(6):618-22. doi: 10.1111/j.1399-6576.1985.tb02267.x.
Coronary sinus pacing was evaluated in 10 pigs during propoxyphene-induced cardiac failure. From baseline, propoxyphene chloride 15 mg . min-1 was infused until circulatory shock developed. Cardiac pacing was evaluated at different dose levels expressed as % of the shock dose of propoxyphene: at intoxication levels below 50% of the shock dose, cardiac pacing improved cardiac performance. At dose levels above 50% of the shock dose cardiac performance deteriorated further during pacing. The results are consistent with a severe negative inotropic effect of propoxyphene in overdose.
在10头猪身上评估了丙氧芬诱导的心力衰竭期间冠状窦起搏情况。从基线开始，以15毫克·分钟-1的速度输注氯丙氧芬，直至发生循环性休克。以丙氧芬休克剂量的百分比表示的不同剂量水平下评估心脏起搏：在中毒水平低于休克剂量的50%时，心脏起搏改善了心脏功能。在剂量水平高于休克剂量的50%时，起搏期间心脏功能进一步恶化。结果与丙氧芬过量时严重的负性肌力作用一致。
