Krantz T, Thisted B, Strøm J, Angelo H, Sørensen M B
J Toxicol Clin Toxicol. 1985;23(4-6):347-52. doi: 10.3109/15563658508990643.
Six patients suffering from cardiovascular failure due to acute propoxyphene overdose, were treated with dopamine infusion in doses of 2-17 microgram/kg/min. All patients responded with increased systolic arterial blood pressure, increased urinary output and decreased central venous pressure. The two most severely poisoned patients showed no increase in heart rate in spite of dopamine infusion in positively chronotropic doses. In two out of three patients the initially abnormal ECGs normalised during treatment. It is concluded that dopamine seems suitable for reversal of propoxyphene induced circulatory failure.
6例因急性丙氧芬过量导致心血管衰竭的患者，接受了剂量为2 - 17微克/千克/分钟的多巴胺输注治疗。所有患者均出现收缩期动脉血压升高、尿量增加及中心静脉压降低。尽管给予了具有正性变时作用剂量的多巴胺输注，但2例中毒最严重的患者心率并未增加。3例患者中有2例在治疗期间最初异常的心电图恢复正常。结论是多巴胺似乎适用于逆转丙氧芬所致的循环衰竭。
