AZTI, Food Research, Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Bizkaia, Astondo Bidea, Edificio 609, Derio 48160, Spain.
Precision Medicine and Metabolism Laboratory, CIC bioGUNE, BRTA, Derio 48160, Bizkaia, Spain.
Prostaglandins Leukot Essent Fatty Acids. 2024 Jan;200:102602. doi: 10.1016/j.plefa.2023.102602. Epub 2023 Dec 15.
The levels of blood eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are very variable and, in general, low in most of the world population. In this study, the effects of age, sex, COVID-19, and dietary habits on the lipid profile of the erythrocyte membranes were assessed in a sub-cohort of healthy population (N = 203) from a large cohort of individuals from the Basque Country, Spain, (AKRIBEA). Sex did not have an effect on RBC lipid profile. COVID-19 infected participants showed higher levels of DGLA. Oldest participants showed higher oleic acid, EPA and DHA levels. Arachidonic acid in RBC correlated positively with the intake of sunflower oil, butter, eggs, processed and red meat, whereas DHA and EPA correlated positively with oily and lean fish. Basque Country population showed lipid profiles similar to other high fish consuming countries, such as Italy and Japan. Baseline levels of the whole lipidomic profile of the RBC including SFA, MUFA and PUFA should be examined to obtain a better description of the health and nutritional status.
血液中二十碳五烯酸 (EPA) 和二十二碳六烯酸 (DHA) 的水平差异很大，而且在世界上大多数人群中普遍较低。在这项研究中，评估了年龄、性别、COVID-19 和饮食习惯对来自西班牙巴斯克地区大型队列中健康人群（N=203）的红细胞膜脂质谱的影响。性别对 RBC 脂质谱没有影响。感染 COVID-19 的参与者表现出更高水平的 DGLA。最年长的参与者表现出更高的油酸、EPA 和 DHA 水平。红细胞中的花生四烯酸与葵花籽油、黄油、鸡蛋、加工肉和红肉的摄入量呈正相关，而 DHA 和 EPA 与油性鱼和瘦鱼呈正相关。巴斯克地区的人群显示出与其他高鱼类消费国家（如意大利和日本）相似的脂质谱。应检查 RBC 全脂质组学谱的基线水平，包括 SFA、MUFA 和 PUFA，以更好地描述健康和营养状况。
