Guo Fanjia, Pan Xinhui, Gu Simeng, Xu Qinghua, Duan Jiafu, Wang Xiaofeng, Chen Zhijian, Fu Qiuli, Mao Guangming, Xu Peiwei, Xu Dandan, Huang Xuemin, Li Yahui, Jiang Yujie, Liu Chenyang, Mo Zhe
Department of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310051, China.
Changshan Center for Disease Control and Prevention, Changshan, 324200, Zhejiang Province, China.
Sci Rep. 2025 Jul 3;15(1):23767. doi: 10.1038/s41598-025-09126-4.
This study aims to investigate associations between PM, PM, and NO and maternal thyroid hormones. We investigated 443 pregnant women in Zhejiang, China with repeated examinations of serum thyroid hormones at 10, 17, and 32 weeks. Individual exposures to ambient air pollution were retrospectively calculated by inverse distance weighting interpolation. Multivariate linear mixed models were applied to estimate the association between air pollutants and thyroid hormones. PM exposure was positively associated with TSH (β: 0.077 [95% CI: 0.003, 0.152]), and negatively associated with FT (β: -0.041 [-0.057, -0.025]) and FT (β: -0.036 [-0.055, -0.017]) during the 0-90 lag days (per IQR). Similarly, increased exposure to PM was associated with decreased FT (β: -0.016 [-0.032, -0.001]), and increased Tg (β: 0.147 [0.025, 0.269]). Evaluated NO levels were associated with decreased FT (β: -0.026 [-0.039, -0.014]) and FT (β: -0.036 [-0.052, -0.020]), as well as increased Tg (β: 0.129 [0.011, 0.247]). The results indicate that exposure to ambient PM, PM, and NO throughout the entire pregnancy adversely affects thyroid hormones, implying potential health implications of air pollution on maternal thyroid function.
本研究旨在调查细颗粒物（PM）、可吸入颗粒物（PM）和一氧化氮（NO）与孕妇甲状腺激素之间的关联。我们对中国浙江的443名孕妇进行了调查，在妊娠10周、17周和32周时对其血清甲状腺激素进行了重复检测。通过反距离加权插值法回顾性计算个体暴露于环境空气污染的情况。应用多元线性混合模型来估计空气污染物与甲状腺激素之间的关联。在0至90天滞后期间（每四分位间距），PM暴露与促甲状腺激素（TSH）呈正相关（β：0.077 [95%置信区间：0.003，0.152]），与游离甲状腺素（FT）（β：-0.041 [-0.057，-0.025]）和游离三碘甲状腺原氨酸（FT）（β：-0.036 [-0.055，-0.017]）呈负相关。同样，PM暴露增加与FT降低（β：-0.016 [-0.032，-0.001]）以及甲状腺球蛋白（Tg）升高（β：0.147 [0.025，0.269]）相关。评估的NO水平与FT降低（β：-0.026 [-0.039，-0.014]）和FT降低（β：-0.036 [-0.052，-0.020]）以及Tg升高（β：0.129 [0.011，0.247]）相关。结果表明，整个孕期暴露于环境中的PM、PM和NO会对甲状腺激素产生不利影响，这意味着空气污染对孕妇甲状腺功能可能具有潜在的健康影响。
