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波兰初级保健机构中早期自闭症筛查的一种拟议算法——一项试点研究。

A proposed algorithm for early autism screening in Polish primary care settings - a pilot study.

作者信息

Domarecki Patryk, Plata-Nazar Katarzyna, Nazar Wojciech

机构信息

BUTTERFLY - Center for Development Support Foundation, Kujawska 8/5A, Morag, 14-300, Poland.

Department of Pediatrics, Gastroenterology, Allergology and Nutrition, Medical University of Gdansk, Nowe Ogrody 1/6, Gdańsk, 80-803, Poland.

出版信息

BMC Prim Care. 2025 Jul 3;26(1):216. doi: 10.1186/s12875-025-02914-x.

Abstract

BACKGROUND

The rising rate of autism spectrum disorder (ASD) prevalence worldwide demands new screening algorithms to make the process of diagnosis more effective. General practitioners and pediatricians are well-positioned to screen all children aged 16 to 30 months during regular check-ups. In the research, the original algorithm for early autism screening in Polish primary care settings was proposed and tested.

METHODS

Based on the literature review, the original algorithm of early autism screening employing observational tool was developed and tested. Personal data and M-CHAT-R/F were collected online. In the second phase, chosen patients participated in the Screening Tool for Autism in Toddlers and Young Children (STAT). Children who scored positive were referred for the comprehensive ASD evaluation. Normal distribution was analyzed with the use of the Shapiro-Wilk test. Chosen variables were compared using the U-Mann Whitney (nonparametric data) or Student's t-test (parametric data). The Spearman's rank correlation coefficient was calculated to analyze the strength of association between selected continuous variables. The threshold of the two-sided statistical significance was set at p < 0.05.

RESULTS

Of 187 parents invited to the project, 159 filled the form in the first phase. According to the protocol, 29 children were chosen for the second stage. 10 children scored positive in the STAT session and were referred for comprehensive evaluation. 5 children out of the seven who attended the evaluation received a final diagnosis of ASD. Parental concerns were found the strongest predictor of M-CHAT-R/F results. Fear of having a child with ASD diagnosis was the most common reason for withdrawal from further steps of the protocol.

CONCLUSIONS

The proposed algorithm for early developmental screening in the Polish primary care settings is a promising pathway with the potential to be implemented in clinical practice. It contributes to the early detection of developmental difficulties and therefore results in positive therapeutic outcomes. Further research is needed.

摘要

背景

全球范围内自闭症谱系障碍(ASD)患病率不断上升,需要新的筛查算法以使诊断过程更有效。全科医生和儿科医生处于有利位置,可在定期检查时对所有16至30个月大的儿童进行筛查。在这项研究中,提出并测试了波兰初级保健机构中早期自闭症筛查的原始算法。

方法

基于文献综述,开发并测试了采用观察工具的早期自闭症筛查原始算法。在线收集个人数据和M-CHAT-R/F。在第二阶段,选定的患者参加了幼儿自闭症筛查工具(STAT)。得分呈阳性的儿童被转介进行全面的ASD评估。使用夏皮罗-威尔克检验分析正态分布。使用U-曼-惠特尼检验(非参数数据)或学生t检验(参数数据)比较选定变量。计算斯皮尔曼等级相关系数以分析选定连续变量之间的关联强度。双侧统计显著性阈值设定为p < 0.05。

结果

在受邀参加该项目的187名家长中,159名在第一阶段填写了表格。根据方案,29名儿童被选入第二阶段。10名儿童在STAT测试中得分呈阳性,并被转介进行全面评估。参加评估的7名儿童中有5名最终被诊断为ASD。发现家长的担忧是M-CHAT-R/F结果的最强预测因素。担心孩子被诊断为ASD是退出方案后续步骤的最常见原因。

结论

在波兰初级保健机构中提出的早期发育筛查算法是一条有前景的途径,有可能在临床实践中实施。它有助于早期发现发育困难,从而带来积极的治疗结果。还需要进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bacc/12224398/b116fd7fd449/12875_2025_2914_Fig1_HTML.jpg

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