有氧运动可降低胰岛素治疗的糖尿病犬运动后长达2小时的间质葡萄糖浓度：一项初步研究。
Aerobic exercise decreases interstitial glucose concentrations up to 2 h after exercise in dogs with insulin-treated diabetes mellitus: a preliminary study.
作者信息
Mampe Jessica R, Stefanovski Darko, Hess Rebecka S
机构信息
Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Department of Clinical Studies-New Bolton Center, School of Veterinary Medicine, University of Pennylvania, Kennett Square, PA, United States.
出版信息
Front Vet Sci. 2025 Jun 19;12:1595952. doi: 10.3389/fvets.2025.1595952. eCollection 2025.
INTRODUCTION
The effect of aerobic exercise on glucose concentration has been reported in healthy normal and over-conditioned dogs and in experimental dog models. However, the effect of aerobic exercise on interstitial glucose concentration (IG) has not been reported in dogs with insulin-treated naturally-occurring diabetes mellitus.
OBJECTIVE
Determine if aerobic exercise decreases IG in outpatient diabetic dogs.
METHODS
Five NPH insulin-treated client-owned diabetic dogs were prospectively enrolled into this interventional longitudinal cohort study. Dogs with a flash glucose monitoring system performed once daily aerobic exercise over 30 min for 7 consecutive days, if IG was 60 mg/dL during the preceding 12 h of observation. Dogs weighing <10 kg exercised (walked or jogged) for 1.5-2 miles, dogs 10-20 kg exercised for 2-2.5 miles, and dogs >20 kg exercised for 2.5-3 miles. Multivariable mixed-effects linear regression models followed by post-hoc analyses were used to estimate the marginal mean differences between IG 0.5, 1, 1.5, 2, and 4 h after exercise compared with marginal mean baseline IG measured twice over 30 min just before each daily exercise period, which served as the control.
RESULTS
Marginal means (95% confidence intervals) of IG were significantly lower 1.5 h after exercise [188 mg/dL (96-281 mg/dL)] and 2 h after exercise [185 mg/dL (82-287 mg/dL)] compared with marginal mean IG measured just before exercise [223 mg/dL (129-317 mg/dL, = 0.03, = 0.008, respectively)]. Marginal means of IG were not significantly different 4 h after exercise compared with marginal mean IG measured just before exercise.
CONCLUSION
Our preliminary data suggest that aerobic exercise may reduce IG levels up to two hours following exercise. These findings indicate that exercise could potentially serve as an adjunct approach to managing insulin-treated diabetic dogs in a home setting.
引言
有氧运动对健康正常和运动过量的犬以及实验犬模型的血糖浓度的影响已有报道。然而，有氧运动对接受胰岛素治疗的自然发生糖尿病的犬的组织间液葡萄糖浓度（IG）的影响尚未见报道。
目的
确定有氧运动是否能降低门诊糖尿病犬的IG。
方法
五只接受中性鱼精蛋白锌胰岛素（NPH）治疗的客户拥有的糖尿病犬被前瞻性纳入这项干预性纵向队列研究。如果在之前12小时的观察期间IG≥60mg/dL，配备实时葡萄糖监测系统的犬连续7天每天进行一次超过30分钟的有氧运动。体重<10kg的犬运动（步行或慢跑）1.5 - 2英里，10 - 20kg的犬运动2 - 2.5英里，体重>20kg的犬运动2.5 - 3英里。使用多变量混合效应线性回归模型并随后进行事后分析，以估计运动后0.5、1、1.5、2和4小时的IG边际均值差异与每天运动期前30分钟内两次测量的边际均值基线IG相比，后者作为对照。
结果
与运动前测量的边际均值IG[223mg/dL（129 - 317mg/dL）]相比，运动后1.5小时[188mg/dL（96 - 281mg/dL）]和运动后2小时[185mg/dL（82 - 287mg/dL）]的IG边际均值显著更低（分别为P = 0.03，P = 0.008）。运动后4小时的IG边际均值与运动前测量的边际均值IG相比无显著差异。
结论
我们的初步数据表明，有氧运动可能在运动后两小时内降低IG水平。这些发现表明，运动有可能作为在家中管理接受胰岛素治疗的糖尿病犬的辅助方法。
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