Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
J Vet Intern Med. 2021 Nov;35(6):2628-2635. doi: 10.1111/jvim.16273. Epub 2021 Oct 2.
A flash glucose monitoring system (FGMS; FreeStyle Libre) is useful for monitoring hypoglycemic dogs with diabetes.
To assess the utility of this FGMS in dogs with induced hypoglycemia and rapid fluctuations in blood glucose (BG) concentrations.
Twenty-four apparently healthy research (n = 10) and teaching (n = 14) dogs.
Prospective, observational study performed in tandem with a teaching laboratory. Regular insulin was administered to dogs and resulting hypoglycemia was corrected. Before insulin administration and every 10 minutes over a 90-minute period, serial measurements of interstitial glucose (IG) with FGMS and BG with a portable blood glucose meter (PBGM) and clinical chemistry analyzer concentrations were made. Portable blood glucose meter and FGMS readings were compared to that of the clinical chemistry analyzer. Analytical and clinical accuracy were assessed using ISO 15197:2013 criteria, including Parkes error grid analysis.
The proportions of readings in the low BG range (BG <100 mg/dL) for which the test method measurement was within ±15 mg/dL of the reference BG for the PBGM and FGMS were 81.7% (161/197) and 39.1% (72/184), respectively. The proportions of readings for the PBGM and FGMS, which were not likely to affect clinical outcome according to Parkes error grid analysis, were 97.9% (233/238) and 80.1% (177/221), respectively.
In this model, there was limited agreement between the FGMS and reference standard BG measurements. The FGMS (measuring IG concentrations) was compared to peripheral BG concentrations, not brain-tissue glucose concentrations, and failed to reliably detect hypoglycemia.
瞬态葡萄糖监测系统（FGMS；FreeStyle Libre）可用于监测患有糖尿病的低血糖犬。
评估该 FGMS 在血糖浓度快速波动的诱导性低血糖犬中的应用价值。
24 只健康的研究（n=10）和教学（n=14）犬。
前瞻性、观察性研究，与教学实验室同时进行。给犬注射常规胰岛素，纠正由此导致的低血糖。在胰岛素给药前和 90 分钟内的每 10 分钟，使用 FGMS 进行连续的间质葡萄糖（IG）测量，使用便携式血糖仪（PBGM）和临床化学分析仪进行连续的血糖浓度测量。比较便携式血糖仪和 FGMS 读数与临床化学分析仪的读数。使用 ISO 15197：2013 标准评估分析和临床准确性，包括 Parkes 误差网格分析。
在 PBGM 和 FGMS 中，测试方法测量值与参考 BG 的差值在 ±15mg/dL 以内的低血糖范围（BG<100mg/dL）读数比例分别为 81.7%（161/197）和 39.1%（72/184）。根据 Parkes 误差网格分析，不会对临床结果产生影响的 PBGM 和 FGMS 读数比例分别为 97.9%（233/238）和 80.1%（177/221）。
在该模型中，FGMS 与参考标准 BG 测量值之间的一致性有限。FGMS（测量 IG 浓度）与外周 BG 浓度进行比较，而不是与脑组织葡萄糖浓度进行比较，并且无法可靠地检测低血糖。
