Qin Chunmei, Li Gang, Yuan Yunhua, Zou Yi
Department of Nephrology, Luzhou People's Hospital, No. 316, Section 2, Jiugu Avenue, Luzhou, 646000, Sichuan, China.
Department of Oncology, Luzhou People's Hospital, Luzhou, China.
Sci Rep. 2025 Jul 8;15(1):24353. doi: 10.1038/s41598-025-09999-5.
Diabetic kidney disease (DKD) is a prevalent chronic condition, with metabolism and inflammation playing crucial roles in its pathogenesis. The uric acid to high-density lipoprotein cholesterol ratio (UHR) represents a novel index reflecting inflammatory and metabolic processes, yet its relationship with DKD remains to be elucidated. This study aimed to investigate the potential association between UHR and DKD.A cross-sectional analysis was conducted utilizing data from the National Health and Nutrition Examination Survey (NHANES, 2001-2018). Weighted multivariate logistic regression was employed to evaluate the association between UHR and DKD, while restricted cubic spline analysis was performed to detect the shape of the dose-response relationships between UHR and DKD. Subgroup analysis were performed to further examine the impact of additional covariates on the UHR-DKD relationship. The study comprised 7,138 patients with diabetes, of whom 2872 (40.24%) were diagnosed with DKD. An increase in the quartile range of UHR was associated with a progressive rise in DKD prevalence (30.51% vs. 32.75% vs. 35.59% vs. 46.72%, P < 0.001).After accounting for different confounding variables, a notable positive link was found between the UHR and DKD.When UHR was treated as a categorical variable, the quartile with the highest UHR showed a 573% increase in DKD prevalence compared to the quartile with the lowest UHR (OR 6.73, 95%CI [1.97, 23.05]). The restricted cubic spline revealed a positive linear correlation between UHR and DKD. Subgroup analyses and interaction tests revealed that age significantly influenced the UHR-DKD relationship (P < 0.05). The findings of this study suggest a significant correlation between UHR and DKD in the adult population of the United States. Nevertheless, further large-scale prospective studies are warranted to substantiate these results.
糖尿病肾病（DKD）是一种常见的慢性疾病，代谢和炎症在其发病机制中起着关键作用。尿酸与高密度脂蛋白胆固醇比值（UHR）是反映炎症和代谢过程的一个新指标，但其与DKD的关系仍有待阐明。本研究旨在探讨UHR与DKD之间的潜在关联。利用美国国家健康与营养检查调查（NHANES，2001 - 2018年）的数据进行横断面分析。采用加权多因素逻辑回归评估UHR与DKD之间的关联，同时进行限制立方样条分析以检测UHR与DKD之间剂量反应关系的形状。进行亚组分析以进一步研究其他协变量对UHR - DKD关系的影响。该研究包括7138例糖尿病患者，其中2872例（40.24%）被诊断为DKD。UHR四分位数范围的增加与DKD患病率的逐步上升相关（30.51%对32.75%对35.59%对46.72%，P < 0.001）。在考虑不同的混杂变量后，发现UHR与DKD之间存在显著的正相关。当将UHR作为分类变量时，UHR最高的四分位数与最低的四分位数相比，DKD患病率增加了573%（比值比6.73，95%置信区间[1.97, 23.05]）。限制立方样条显示UHR与DKD之间存在正线性相关。亚组分析和交互检验显示年龄显著影响UHR - DKD关系（P < 0.05）。本研究结果表明在美国成年人群中UHR与DKD之间存在显著相关性。然而，仍需要进一步的大规模前瞻性研究来证实这些结果。
