Davidson Pamela L, Nakazono Terry T, Min Andrea, Morrison Jim, Quail Omira
CTSI-Evaluation, Clinical and Translational Science Institute (CTSI), University of California, Los Angeles, Los Angeles, CA, United States.
Department of Health Policy and Management, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, United States.
Front Public Health. 2025 Jun 19;13:1565096. doi: 10.3389/fpubh.2025.1565096. eCollection 2025.
Demonstrating impact in the Clinical and Translational Science Award (CTSA) Program is crucial to continue governmental, taxpayer, institutional, and donor support and investment. We present an innovative portfolio analysis to summarize the Scientific Achievement Translational Science Impact at the hub level. Additionally, a unique feature of the UCLA CTSA hub includes the many interorganizational collaborations with Los Angeles County (LAC). This is the first study to examine the Translational Science Benefits Model (TSBM) impact on projects with CTSA hub-county interorganizational collaborations. A Framework for Evaluating Scientific Achievement Translational Science Impact (SATSI) was used to guide the analyses, with impact indicators derived from the TSBM: (i) clinical and medical, (ii) community and public health, (iii) economic, and (iv) policy and legislation. Two major data sources were used for the evaluation: (i) The CTSI's Longitudinal Scientific Achievement and Impact survey (LSAS-I), and (ii) longitudinal interviews with principal investigators who reported high-impact projects in hub-county collaborations. We reported baseline data from 2 years of LSAS-I data showing = 507 new CTSA-assisted grants and the associated demonstrated and potential impact using the hub portfolio analysis. Eighteen ( = 18) of these grants involved a hub-county interorganizational collaboration. Among these, we identified the highest impact projects and developed impact stories and vignettes describing improvements in health care delivery and population health. Our research offers a model for other CTSA hubs to summarize impact using the hub portfolio analysis, and to partner with local public health departments and governmental agencies to address health concerns in low-income and at-risk populations. This research directly addresses the mission of the UCLA hub, "to produce and implement innovations that impact the greatest health needs of Los Angeles and the nation."
在临床与转化科学奖（CTSA）项目中展示影响力对于持续获得政府、纳税人、机构和捐赠者的支持与投资至关重要。我们提出了一种创新的投资组合分析方法，以总结枢纽层面的科学成就转化科学影响力。此外，加州大学洛杉矶分校CTSA枢纽的一个独特之处在于与洛杉矶县（LAC）开展了众多组织间合作。这是第一项研究转化科学效益模型（TSBM）对CTSA枢纽 - 县组织间合作项目影响的研究。我们使用了评估科学成就转化科学影响力（SATSI）框架来指导分析，影响指标源自TSBM：（i）临床与医学，（ii）社区与公共卫生，（iii）经济，以及（iv）政策与立法。评估使用了两个主要数据来源：（i）CTSI的纵向科学成就与影响调查（LSAS - I），以及（ii）对在枢纽 - 县合作中报告有高影响力项目的主要研究者进行的纵向访谈。我们报告了来自LSAS - I两年数据的基线数据，展示了n = 507项新的CTSA资助项目以及使用枢纽投资组合分析得出的相关已证明和潜在影响。其中18项（n = 18）资助项目涉及枢纽 - 县组织间合作。在这些项目中，我们确定了影响力最大的项目，并编写了影响故事和案例，描述医疗服务提供和人群健康方面的改善。我们的研究为其他CTSA枢纽提供了一个模型，用于使用枢纽投资组合分析总结影响力，并与当地公共卫生部门和政府机构合作，解决低收入和高危人群的健康问题。这项研究直接呼应了加州大学洛杉矶分校枢纽的使命，即“产生并实施能够影响洛杉矶和美国最大健康需求的创新”。
