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1990年至2021年非传染性疾病所致失明和视力丧失负担的全球趋势与差异，以及到2045年的预测：全球疾病负担研究2021的系统分析

Global trends and disparities in burden of blindness and vision loss caused by non-communicable diseases from 1990 to 2021, and forecasts to 2045: a systematic analysis for the global burden of disease study 2021.

作者信息

Ye Lingxia, Huang Xin, Xu Yufeng

机构信息

Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Department of Endocrinology and Metabolism, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Municipal Central Hospital, Lishui, China.

出版信息

Front Med (Lausanne). 2025 Jun 19;12:1561568. doi: 10.3389/fmed.2025.1561568. eCollection 2025.

DOI:10.3389/fmed.2025.1561568
PMID:40612577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12222054/
Abstract

BACKGROUND: Blindness and vision loss (BVL) is a major public health concern. Non-communicable diseases (NCDs), including cataract, glaucoma, age-related macular degeneration, diabetic retinopathy and etc., were the leading causes of vision impairment globally. METHODS: We extracted global, regional, national, age-and sex-specific data on the prevalence and years lived with disability (YLDs) of BVL caused by NCDs from the Global Burden of Disease Study 2021 (GBD 2021), and then conducted a secondary comparative analysis based on time, location, age, gender, socioeconomic development index (SDI) and health system level. RESULTS: From 1990 to 2021, the global incidence of BVL caused by NCDs continuously increased. In 2021, 1475648.6 thousand BVL cases caused by NCDs occurred globally, and ASR of YLDs reached 371.1 per 100,000 population. Great disparities were found across different genders, ages, and locations. Higher burdens were noted among females, older adult individuals, regions with lower SDI or less advanced health systems. CONCLUSION: The burden of BVLs caused by NCDs has increased significantly since 1990 and varies widely across regions. Greater efforts are needed in NCDs control and vision protection, especially in older adult individuals and females, in regions with lower SDI, and in regions with less advanced health systems.

摘要

背景：失明和视力丧失是一个重大的公共卫生问题。包括白内障、青光眼、年龄相关性黄斑变性、糖尿病视网膜病变等在内的非传染性疾病是全球视力损害的主要原因。 方法：我们从《2021年全球疾病负担研究》（GBD 2021）中提取了关于非传染性疾病导致的失明和视力丧失的患病率及失能生存年数（YLDs）的全球、区域、国家、年龄和性别特异性数据，然后基于时间、地点、年龄、性别、社会经济发展指数（SDI）和卫生系统水平进行了二次比较分析。 结果：1990年至2021年，非传染性疾病导致的全球失明和视力丧失发病率持续上升。2021年，全球发生了1475648.6千例由非传染性疾病导致的失明和视力丧失病例，YLDs的年龄标准化率达到每10万人口371.1。在不同性别、年龄和地点之间发现了巨大差异。女性、老年人、SDI较低或卫生系统较不发达地区的负担更高。 结论：自1990年以来，非传染性疾病导致的失明和视力丧失负担显著增加，且各地区差异很大。在非传染性疾病控制和视力保护方面需要做出更大努力，特别是在老年人和女性、SDI较低的地区以及卫生系统较不发达的地区

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34c1/12222054/0ed6ad1a8a17/fmed-12-1561568-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34c1/12222054/46f3b5ae87e2/fmed-12-1561568-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34c1/12222054/4f0de50a6bb3/fmed-12-1561568-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34c1/12222054/2149990fec31/fmed-12-1561568-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34c1/12222054/77a48cfe50a0/fmed-12-1561568-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34c1/12222054/0ed6ad1a8a17/fmed-12-1561568-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34c1/12222054/46f3b5ae87e2/fmed-12-1561568-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34c1/12222054/4f0de50a6bb3/fmed-12-1561568-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34c1/12222054/2149990fec31/fmed-12-1561568-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34c1/12222054/77a48cfe50a0/fmed-12-1561568-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34c1/12222054/0ed6ad1a8a17/fmed-12-1561568-g005.jpg

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本文引用的文献

[1]
Global, regional and national burden of Glaucoma: an update analysis from the Global Burden of Disease Study 2019.

Int Ophthalmol. 2024-6-19

[2]
Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.

Lancet. 2024-5-18

[3]
Investigating the Impact of Sun/UV Protection and Ease of Skin Tanning on the Risk of Pseudoexfoliation Glaucoma: A Mendelian Randomization Study.

Invest Ophthalmol Vis Sci. 2023-10-3

[4]
Trends and disparities in disease burden of age-related macular degeneration from 1990 to 2019: Results from the global burden of disease study 2019.

Front Public Health. 2023

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Endocrine. 2021-8

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Global economic productivity losses from vision impairment and blindness.

EClinicalMedicine. 2021-4-26

[7]
The Association of Socioeconomic Status with the Burden of Cataract-related Blindness and the Effect of Ultraviolet Radiation Exposure: An Ecological Study.

Biomed Environ Sci. 2021-2-20

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Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study.

Lancet Glob Health. 2021-2

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Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study.

Lancet Glob Health. 2021-2

[10]
Visual impairment and ten-year mortality: the Liwan Eye Study.

Eye (Lond). 2021-8

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