Serralabós-Ferré J, Barceló-Carceller I
Pediatrics, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Toxicol Rep. 2025 Jan 7;14:101889. doi: 10.1016/j.toxrep.2024.101889. eCollection 2025 Jun.
Anticholinergic syndrome consists of neurological and systemic symptoms, including agitation, mydriasis and dryness that can be an adverse reaction to a number of medications, some of them as seemly harmless as cycloplegic mydriatic drops. We present the case of a 7-year-old previously healthy female child who presented to the emergency room with impaired neurological status, inability to recognize family members and incoherent speech, as well as facial flushing, mucosal dryness and bilateral mydriasis after having mistakenly received a high dose of mydriatic drops. She made a complete recovery without need for treatment and had no sequelae. It has been described that anticholinergic syndrome can be related to a number of mydriatic drops (such as cyclopentolate) as well as other medications, in adults, children and neonates. It is a clinical diagnosis and requires no etiological testing. Depending on the severity at presentation, it may be required to administer the antidote physostigmine.
抗胆碱能综合征包括神经和全身症状，如烦躁、瞳孔散大及口干，这可能是多种药物的不良反应，其中一些药物看似无害，如睫状肌麻痹散瞳滴眼液。我们报告一例7岁既往健康的女童，她因误服高剂量散瞳滴眼液后出现神经功能障碍、无法识别家庭成员、言语不清，以及面部潮红、黏膜干燥和双侧瞳孔散大而被送往急诊室。她未经治疗完全康复，且无后遗症。已有报道称，抗胆碱能综合征在成人、儿童和新生儿中可与多种散瞳滴眼液（如环喷托酯）以及其他药物有关。这是一种临床诊断，无需进行病因学检查。根据就诊时的严重程度，可能需要使用解毒剂毒扁豆碱。
